alzheimer’s disease (ad) is a neurodegenerative disease characterized by cognitive and other cns impairments which is increasing worldwide and poses a major public health problem, yet no effective treatments are found and available drugs only alleviate the symptoms temporarily. postmortem analyses on the brains of ad patients and observed lower risk of ad in nsaids users among other studies hav...

objective(s): according to the occupationally risk of infection in staff workers who have direct contact with mycobacterium species, we investigated their immunological parameters and compared with healthy purified protein derivative (ppd) negative volunteers.   materials and methods : we investigated 20 ppd positive volunteers working at tuberculin unit of razi vaccine and serum research insti...

introduction: multiple sclerosis (ms) has been recognized as a common neurodegenerative disease that occurs after an auto reactive t cells against myelin antigens.  demyelination and inflammation are the main features of this disease. the anti-inflammatory and neuroprotective roles of bone marrow-derived mesenchymal stem cells (bm-mscs) have been considered as a suitable treatment against autoi...

t cells have been identified as key players in the pathogenesis of type 1 diabetes. however, the exact role of t-cell subpopulations in this pathway is presently unknown. the purpose of this study was to assess the expression pattern of two lineage-specifying transcription factors gata - 3 and t - bet , which are important in t helper type 1 (th1) and th2 cell development , respectively. gene e...

Interleukin (IL)-17 is exclusively produced by CD4 helper T-cells upon activation. It most often acts as a pro-inflammatory cytokine, which stimulates the release of pro-inflammatory cytokines IL-6, IL-8, TNF-α, and granulocyte-macrophage colony-stimulating factor (GM-CSF). In this study, we studied the in-vitro IL-17 response to specific antigens and a variety of mitogens and compared the IL-1...

Background: Acute kidney injury (AKI) is defined as a failure in renal function leading to insufficiency of fluid and electrolyte homeostasis. Thus, sensitive biomarkers of renal tubular injury are needed to detect AKI earlier. In this study, urinary beta 2-microglobulin (β2-MG) and urinary N-acetyl-β-D-glucosaminidase (NAG) were evaluated for AKI prognosis/diagnosis in pediatric patients suffe...

in order to determine the frequency rate of urinary stress incontinence (s.i) after delivery and related factors a longitudinal study carried on primiparous women in arash hospital in 1379. through a non probability sampling, 400 eligible women were recruited from available population. patient with complain of urinary stress incontinence on third day after delivery, were examined and undergone ...

opium use is one of the most common forms of substance abuse in iran and there are some evidence indicating it is a risk factor of transitional cell carcinoma (tcc) of the urinary bladder. the majority of opium users are also cigarette smokers, so consideration of the high prevalence of smoking which is the most important risk factor of tcc of the urinary bladder among opium users is essential ...

Background: Although many experimental studies provide convincing evidence that type II immunity is protective against helminths, recent data in mice demonstrate that Th1 is also impor-tant in some cestodes like Hymenolepis nana. Objective: To identify the role of Th1 and Th2 lymphocytes in immunity against H. nana, the levels of IL-12, IFNγ, IL-5, and IL-13 were de-termined in serum of humans ...