نتایج جستجو برای: urea transporter b expression

تعداد نتایج: 1715338  

Journal: :Journal of the American Chemical Society 2008
Beth A McNally Edward J O'Neil Anh Nguyen Bradley D Smith

A new type of synthetic membrane transporter is described and shown to operate in vesicles by a relay mechanism. The transporter structure is a phosphatidylcholine derivative with a urea group appended to the end of its sn-2 acyl chain. The urea can bind a chloride ion at the membrane surface via hydrogen bonds and then relay it through the bilayer interior to an acceptor molecule located in th...

Journal: :International Journal of Molecular Sciences 2013

Journal: :Journal of the American Society of Nephrology : JASN 2007
Jeff M Sands

T he ability to produce concentrated or dilute urine allows people to vary water excretion to match water intake, thereby maintaining a nearly constant blood plasma osmolality. This is accomplished in the renal medulla through the combined actions of several transport proteins in the loops of Henle, collecting ducts, and vasculature and the complex but unique spacial relationship that these str...

Journal: :The Journal of experimental biology 2013
Chris M Wood C Michele Nawata Jonathan M Wilson Pierre Laurent Claudine Chevalier Harold L Bergman Adalto Bianchini John N Maina Ora E Johannsson Lucas F Bianchini Geraldine D Kavembe Michael B Papah Rodi O Ojoo

The small cichlid fish Alcolapia grahami lives in Lake Magadi, Kenya, one of the most extreme aquatic environments on Earth (pH ~10, carbonate alkalinity ~300 mequiv l(-1)). The Magadi tilapia is the only 100% ureotelic teleost; it normally excretes no ammonia. This is interpreted as an evolutionary adaptation to overcome the near impossibility of sustaining an NH3 diffusion gradient across the...

Journal: :iranian journal of pharmaceutical research 0
mitra hassany biotechnology research center, mashhad university of medical sciences, mashhad, iran. mohammad hassanzadeh khayat faculty of pharmacy, mashhad university of medical sciences, mashhad, iran. pharmaceutiacal sciences research center, mashhad university of medical sciences, mashhad, iran. javaad behravan biotechnology research center, mashhad university of medical sciences, mashhad, iran. faculty of pharmacy, mashhad university of medical sciences, mashhad, iran. jamaal kasaeeian biotechnology research center, mashhad university of medical sciences, mashhad, iran.

the drug pump protein mrp2 is a membrane drug efflux transporter widely distributed in normal and tumor tissues. its role is thought to be crucial for the disposition of many drugs and their substrates in different tissues. in this study, we aimed to examine the effects of systematic inflammation induced by lipopolysaccharide (lps) on the expression and function of this transporter in rats. jug...

Journal: :American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 2009

Journal: :Journal of the American Society of Nephrology 2005

Journal: :Biochimica et Biophysica Acta (BBA) - Biomembranes 1999

Jamaal Kasaeeian Javaad Behravan, Mitra Hassany Mohammad Hassanzadeh Khayat

The drug pump protein MRP2 is a membrane drug efflux transporter widely distributed in normal and tumor tissues. Its role is thought to be crucial for the disposition of many drugs and their substrates in different tissues. In this study, we aimed to examine the effects of systematic inflammation induced by lipopolysaccharide (LPS) on the expression and function of this transporter in rats. Jug...

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