Plasma obtained from fasted humans has been analysed for total radical-trapping antioxidant content by subjecting it to controlled peroxidation using the thermal decomposition of water-soluble azobis (2-amidinopropane hydrochloride) at 37 degrees C to produce peroxyl radicals at a known, steady rate. It is found that the total radical-trapping antioxidant content is rather similar for the 7 sub...

We examine the correlation in credit risk using credit default swap (CDS) data. We find that the observable risk factors at the firm, industry, and market levels and the macroeconomic variables cannot fully explain the correlation in CDS spread changes, leaving at least 30 percent of the correlation unaccounted for. This finding suggests that contagion is not only statistically but also economi...

Title: Etiology of Isolated Pontine Infarctions: A Study Based on High-Resolution MRI and Brain Small Vessel Disease scores Authors: Cheng Xia ([email protected]) Hui-Sheng Chen ([email protected]) Shi-Wen Wu ([email protected]) Wei-Hai Xu ([email protected]) Version: 3 Date: 29 Nov 2017 Author’s response to reviews: 1. Availability of Data and Materials: As per the editorial policies, we requir...

Different dependence scenarios can arise in multivariate extremes, entailing careful selection of an appropriate class of models. In bivariate extremes, the variables are either asymptotically dependent or are asymptotically independent. Most available statistical models suit one or other of these cases, but not both, resulting in a stage in the inference that is unaccounted for, but can substa...

Nonsymmetric correspondence analysis (NSCA) aims to examine predictive relationships between rows and columns of a contingency table. The predictor categories of such tables are often accompanied by some auxiliary information. Constrained NSCA (CNSCA) incorporates such information as linear constraints on the predictor categories. However, imposing constraints also means that part of the predic...

Theoretical predictions about the evolution of selfing depend on the genetic architecture of loci controlling selfing (monogenic vs. polygenic determination, large vs. small effect of alleles, dominance vs. recessiveness), and studies of such architecture are lacking. We inferred the genetic basis of mating system differences between the outbreeding Mimulus guttatus and the inbreeding M. platyc...

The hydroxyl radical (OH) removes most atmospheric pollutants from air. The loss frequency of OH radicals due to the combined effect of all gas-phase OH reactive species is a measureable quantity termed total OH reactivity. Here we present total OH reactivity observations in pristine Amazon rainforest air, as a function of season, time-of-day and height (0-80 m). Total OH reactivity is low duri...

Background Congenital Indifference to Pain (CIP) is a rare condition that inhibits the ability of patients to perceive physical pain but otherwise keeps normal sensory modalities. The condition has been mapped to an autosomal recessive trait to chromosome 2q 24.3 with mutations on the SCN9A gene. Case report A 2 year old Caucasian female presented with CIP. Bite injuries, tongue wounds and unac...

In high-dimensional settings, where the number of features p is much larger than the number of samples n, methods that systematically examine arbitrary combinations of features have only recently begun to be explored. However, none of the current methods is able to assess the association between feature combinations and a target variable while conditioning on a categorical covariate. As a resul...

Neonatal deaths account for 43% of under-5 childhood deaths in Kenya. Most infants are born at home, and many of them die at home unaccounted for, often during the first week of life. Previous studies in which community health workers (CHWs) were trained to provide neonatal care reported reductions in neonatal mortality. These programmes required more resources than may be available in some res...