Human mesenchymal stem cells derived from the umbilical cord (UC) are a favorable source for allogeneic cell therapy. Here, we successfully isolated the stem cells derived from three different compartments of the human UC, including perivascular stem cells derived from umbilical arteries (UCA-PSCs), perivascular stem cells derived from umbilical vein (UCV-PSCs), and mesenchymal stem cells deriv...

OBJECTIVE To relate Doppler velocimetry findings in fetoplacental and uteroplacental circulation to placental histomorphology. MATERIAL AND METHODS In 14 uncomplicated and 31 high-risk pregnancies Doppler velocimetry was performed in umbilical artery and vein, and in maternal uterine veins and arteries during the second half of gestation. Histopathology of the placentas was examined, especial...

A 20-year-old woman, gravid-1 para-0, was referred to the Gynaecology and Obstetrics Department at 21-weeks gestation with a diagnosis of CT in a spontaneous triplet pregnancy. There was no history of twinning in the family and medication use during early pregnancy. At referral, transvaginal ultrasound revealed a monochorionic-diamniotic triplet pregnancy with a set of CTs. One amniotic sac con...

OBJECTIVE Alteration to blood flow in the maternal-foetal compartment has been proposed as a mechanism underlying maternal psychological effects on pregnancy outcomes. This study characterised the progression of umbilical and uterine blood flow resistance in healthy pregnancies and evaluated concurrent and longitudinal associations with maternal anxiety and other psychological factors. METHOD...

Aim—To determine whether antenatal administration of thyrotrophin releasing hormone (TRH), to promote lungmaturation, alters blood flow through the fetal middle cerebral, umbilical artery, or ductus arteriosus and through the maternal uterine arteries. Methods—The eVect of transplacentally administered TRH on the fetal circulation was prospectively evaluated in 30 patients between 24 and 34 wee...

The rock cavies (Kerodon rupestris) are rodents belonging to family Caviidae, with habitat restricted to northeastern Brazil. Current studies have shown that blood cord has stem and hematopoietic cells both with a high regenerative potential, microscopic studies about the description in rodents and other mammals are scarce. The aim of this study was to describe the structural components of the ...

To study nutrition and metabolism in the fetal pig, a chronic catheterization method was developed that allows blood sampling in arteries and veins, at both the umbilical and uterine sources, in the conscious, unstressed animal. A catheter was inserted in the fetal aorta through a femoral artery, and another one was introduced in the umbilical vein. A catheter was put in a femoral artery of the...

34 35 The present study was conducted to determine the impact of suppressing trophoblast 36 remodeling of the uterine spiral arteries by prematurely elevating estrogen levels in the first 37 trimester of baboon pregnancy on uterine and umbilical blood flow dynamics. Uteroplacental 38 blood flow was assessed by Doppler ultrasonography after acute administration of saline (basal 39 state) and ser...

The twin-twin transfusion syndrome (TTTS) is a severe complication of monochorionic twin pregnancies caused by a net transfusion of blood from one twin (the donor) to the other (the recipient) through placental anastomoses. To examine the pathophysiology of TTTS evolving through clinical stages I to IV, we extended our mathematical model to include pulsating circulations propagating along the a...