نتایج جستجو برای: ultrasound microbubble

تعداد نتایج: 109355  

Journal: :Stroke 2016
Yongkang Lu Junfen Wang Ruizhu Huang Gangbin Chen Lintao Zhong Shuxin Shen Chuanxi Zhang Xinzhong Li Shiping Cao Wangjun Liao Yulin Liao Jianping Bin

BACKGROUND AND PURPOSE Microthrombi originating from disintegrated clots or formed in situ may account for the poor clinical improvement of acute ischemic stroke after recanalization therapy. We attempted to determine whether microbubble-mediated sonothrombolysis could dissolve platelet-rich and erythrocyte-rich microthrombi, thereby reducing their brain injury-causing potential. METHODS Plat...

Journal: :The journal of extra-corporeal technology 2014
Daniel P Herbst

Micropore filters are used during extracorporeal circulation to prevent gaseous and solid particles from entering the patient's systemic circulation. Although these devices improve patient safety, limitations in current designs have prompted the development of a new concept in micropore filtration. A prototype of the new design was made using 40-μm filter screens and compared against four comme...

Journal: :The British journal of surgery 2009
H Guo J C K Leung J S Cheung L Y Y Chan E X Wu K N Lai

BACKGROUND Postoperative intra-abdominal adhesion is associated with high morbidity and mortality. Smad7, a protein that occupies a strategic position in fibrogenesis, inhibits the transforming growth factor (TGF) beta/Smad signalling pathway. In this study the therapeutic potential of exogenous Smad7 in preventing fibrogenesis in postoperative intra-abdominal adhesion was investigated. METHO...

2017
Joseph S. D’Arrigo

Owing to the complexity of neurodegenerative diseases, multiple cellular types need to be targeted simultaneously in order for a given therapy to demonstrate any major effectiveness. Ultrasound-sensitive coated microbubbles (in a targeted nanoemulsion) are available. Versatile small-molecule drug(s) targeting multiple pathways of Alzheimer’s disease pathogenesis are known. By incorporating such...

Journal: :Investigative radiology 2001
A Y Kim B I Choi T K Kim K W Kim J Y Lee J K Han

RATIONALE AND OBJECTIVES To investigate the feasibility of recent contrast-specific ultrasound techniques in depicting vascular flow and the effects of changing the output power of the transducer and insonation mode on contrast enhancement, the authors performed an experimental study with a flow phantom. METHODS While changing the mechanical index and the sound insonation mode (continuous and...

Journal: :Interface focus 2011
M-X Tang H Mulvana T Gauthier A K P Lim D O Cosgrove R J Eckersley E Stride

Ultrasound provides a valuable tool for medical diagnosis offering real-time imaging with excellent spatial resolution and low cost. The advent of microbubble contrast agents has provided the additional ability to obtain essential quantitative information relating to tissue vascularity, tissue perfusion and even endothelial wall function. This technique has shown great promise for diagnosis and...

2017
Hiroyuki Yamaguchi Yuji Ishida Jun Hosomichi Jun-Ichi Suzuki Kasumi Hatano Risa Usumi-Fujita Yasuhiro Shimizu Sawa Kaneko Takashi Ono

Periodontitis is a chronic infectious disease for which the fundamental treatment is to reduce the load of subgingival pathogenic bacteria by debridement. However, previous investigators attempted to implement a nuclear factor kappa B (NF-κB) decoy oligodeoxynucleotide (ODN) as a suppressor of periodontitis progression. Although we recently reported the effectiveness of the ultrasound-microbubb...

Journal: :Molecular imaging 2010
Ryan Gessner Paul A Dayton

Ultrasound imaging has long demonstrated utility in the study and measurement of anatomic features and noninvasive observation of blood flow. Within the last decade, advances in molecular biology and contrast agents have allowed researchers to use ultrasound to detect changes in the expression of molecular markers on the vascular endothelium and other intravascular targets. This new technology,...

2014
Paul S. Sheeran Paul A. Dayton

Over the past two decades, perfluorocarbon (PFC) droplets have been investigated for biomedical applications across a wide range of imaging modalities. More recently, interest has increased in "phase-change" PFC droplets (or "phase-change" contrast agents), which can convert from liquid to gas with an external energy input. In the field of ultrasound, phase-change droplets present an attractive...

Journal: :World journal of gastroenterology 2008
Ying Wang Hui-Xiong Xu Ming-De Lu Qing Tang

AIM To investigate the killing efficiency of a recombinant plasmid containing a thymidine kinase (TK) domain insert driven by the vascular endothelial growth factor receptor 2 (VEGFR2) promoter (KDR) on vascular endothelial cells. METHODS The KDR-TK fragment was extracted from pBluescript II KDR-TK plasmid by enzymatic digestion with XhoI and SalI. The enhanced green fluorescence protein (EGF...

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