The optimization of a Ugi reaction involving the mixing of furfurylamine, benzaldehyde, boc-glycine and t-butylisocyanide is described. Triplicate runs of 48 parallel experiments are reported, varying concentration, solvent and the excess of some of the reagents. The isolation of the product was achieved by a simple filtration and wash procedure. The highest yield obtained was 66% from 0.4 M me...

Polyeptoids are a promising class of polypeptide mimetic biopolymers based on N-substituted glycine backbones. Because the high designability their side chains, polypeptoids have wide range applications in surface antifouling, biosensing, drug delivery, and stimuli-responsive materials. To better control structures properties polypeptoids, it is necessary to understand different methods for pol...

A convenient base-mediated two-step synthesis of cotinine analogs and a one-pot base-free synthesis of iso-cotinine derivatives featuring an Ugi-4CR/cyclization protocol are reported. These approaches exploit the reactivity of the peptidyl position present in the Ugi adducts, allowing the facile construction of the γ-lactam core, as well as the introduction of a N-substituted methyl group into ...