Nasopharyngeal carcinoma (NPC) is a malignancy of epithelial origin. The etiology of NPC is complex and includes multiple genetic and environmental factors. We employed case-control analysis to study the association of chromosome 6p regions with NPC. In total, 360 subjects and 360 healthy controls were included, and 233 single nucleotide polymorphisms (SNPs) on 6p were examined. Significant sin...

Small ubiquitin like modifier (SUMO) proteins are known to regulatemany important cellular processes such as transcription and apoptosis. Recently, hybrid SUMO-ubiquitin chains containing SUMO-2 linked to Lys63-di-ubiquitin were found to play a major role in DNA repair. Despite some progress in understanding the role of these hybrid chains in DNA repair, there are various fundamental questions ...

RIG-I is a key cytosolic RNA sensor that mediates innate immune defense against RNA virus. Aberrant RIG-I activity leads to severe pathological states such as autosomal dominant multi-system disorder, inflammatory myophathies and dermatomyositis. Therefore, identification of regulators that ensure efficient defense without harmful immune-pathology is particularly critical to deal with RIG-I-ass...

Over the past three decades, substantial progress has been made in understanding the genetic basis for diabetes. One of the important first steps that allowed this progress to occur was realizing that diabetes is heterogeneous, and, therefore, separation of clinically distinct forms of the disorder (i.e., type 1 vs. type 2 diabetes) improves the ability to detect genetic associations. The key p...

Post-translational modification of proteins with ubiquitin (Ub) and Ub chains controls protein breakdown by the proteasome, cellular localization of proteins, transcriptional activity, and DNA repair. Ubiquitin is a highly conserved 76 amino acid protein that can be linked to target proteins through an isopeptide bond between the C-terminal carboxylate of Ub and the e-amine of a lysine residue ...

The objective of this study was to screen for ubiquitination-associated proteins involved in cisplatin resistance in a human lung adenocarcinoma cell strain using a comparative proteomic strategy. We employed 1D SDS-PAGE to separate ubiquitinated proteins isolated and enriched from A549 and A549/CDDP lysates via affinity chromatography. The differentially expressed bands between 45-85 kDa were ...

This paper proposes the designing of regional compensation type Dynamic Voltage Restorer(DVR), and the topology of main circuit, the detection algorithm for voltage sag, the calculation method of reference voltage and pulse modulation method. Based on the different load types of the target substation and the sensitivity to voltage sags, the selection principle of the location of compensation li...

•Protease protection coupled APEX2 proximity proteomics of autophagosomes•Identification selective autophagy receptor-dependent cargo•Ubl conjugation and protein aggregation only modestly drive cargo engulfment•The aggrephagy receptor TOLLIP is implicated in endosomal microautophagy Autophagy deficiency fed conditions leads to the formation inclusions highlighting contribution this lysosomal de...

NFB is a central mediator of innate immunity and contributes to the pathogenesis of several renal diseases. FAT10 is a TNF–inducible ubiquitin-like protein with a putative role in immune response, but whether FAT10 participates in TNF–induced NFB activation is unknown. Here, using renal tubular epithelial cells (RTECs) derived from FAT10 / and FAT10 / mice, we observed that FAT10 deficiency abr...

•Biochemical reaction states are approximated with PCA-transformed RNA-seq count data•Our graph neural network outperforms both random rewired and deep learning controls•Analysis of our model reveals reactions associated psoriasis in prior studies•Traditional analysis approaches fail to discover the found method The Human Genome Project unlocked door a vast but unannotated collection genes. In ...