نتایج جستجو برای: type vii collagen
تعداد نتایج: 1402056 فیلتر نتایج به سال:
objective(s): osteoarthritis is one of the most common diseases in middle-aged population in the world. cartilage tissue engineering (te) has been presented as an effort to introduce the best combination of cells, biomaterial scaffolds and stimulating growth factors to produce a cartilage tissue similar to the natural articular cartilage. in this study, the chondrogenic potential of adipose der...
Purpose: In this study specific antibody have been used for tracing type IV collagen basement membrane during renal tubules morphogenesis in mouse fetuses. Materials and Methods: 20 female Balb/C mice were selected randomly and were kept under normal condition, finding vaginal plug was assumed as day zero of pregnancy. 12 pregnant mice were scarified by cervical dislocation in one of gestationa...
Human induced pluripotent stem cell (hiPSC)-derived hair-bearing skin organoids offer exciting new possibilities for modelling diseases like epidermolysis bullosa. These inherited affect 1 in 30,000 people worldwide and result from perturbed expression and/or structure of components the epidermal-dermal junction, interface between basal keratinocytes epidermis stroma dermis. To establish whethe...
Alpha-helical coiled-coil oligomerization domains are almost ubiquitous in the collagen superfamily.
Alpha-helical coiled-coils are widely occurring protein oligomerization motifs. Here we show that most members of the collagen superfamily contain short, repeating heptad sequences typical of coiled coils. Such sequences are found at the N-terminal ends of the C-propeptide domains in all fibrillar procollagens. When fused C-terminal to a reporter molecule containing a collagen-like sequence tha...
Skin aging is a biological process that is due to the reduction of collagen production and increase of multiple enzymes, including matrix metalloproteinase (MMPS), which degrade collagen. Chlorella vulgaris is a marine microalga and its beneficial effects on the skin make it a proper ingredient to be used in anti-aging products. In this study, the effect of C. vulgaris extract comparing to vita...
Clonal gene therapy protocols based on the precise manipulation of epidermal stem cells require highly efficient gene-editing molecular tools. We have combined adeno-associated virus (AAV)-mediated delivery of donor template DNA with transcription activator-like nucleases (TALE) expressed by adenoviral vectors to address the correction of the c.6527insC mutation in the COL7A1 gene, causing rece...
For the extraction of type IV collagen, the normal placenaes at term were placed under pepsin digestion (once). To purify the extracted collagen, Saltingout and changing the PH were performed (each step twice). All steps of the extraction and purification were controlled by the SDS-PAGE electrophoresis and finally purified collagen with molecular weight 170 and 185 KD chains were obtain...
Purpose: In this investigation specific antibody type IV collagen has been used in light microscopy to study development of BMG of the embryonic and postnatal mouse glomerular mesangium. Materials and Methods:20 female Balb/C mice were selected randomly and were kept under normal condition, finding vaginal plug was assumed as day zero of pregnancy. 12 pregnant mice were scarified by cervical di...
Objective(s): Osteoarthritis is one of the most common diseases in middle-aged population in the world. Cartilage tissue engineering (TE) has been presented as an effort to introduce the best combination of cells, biomaterial scaffolds and stimulating growth factors to produce a cartilage tissue similar to the natural articular cartilage. In this study, the chondrogenic potential of adipose d...
While inherited and acquired diseases have proven invaluable in increasing our understanding of the basement membrane zone (BMZ), the identification of the genes of various BMZ proteins and the development of advanced molecular techniques has allowed for the development of many new animal models, which present a great opportunity for increasing our knowledge of BMZ biology, the pathogenesis of ...
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