Background and Purpose: Candidiasis, an important fungal infection, is considered the fourth most common nosocomial blood stream infection. Nowadays, because of increased fungal resistance to antibiotics, the use of herbal medicine has gained particular attention. Cyclamen species are medicinal plants containing triterpenoid saponins, which are shown to have antimicrobial properties. Materi...

In our previous studies, quantified saponins-rich fraction from adventitious root extract of Ficus religiosa L., Moraceae, showed anticonvulsant effect in acute, as well as chronic mice models of epilepsy. The present study was designed to reveal putative anticonvulsant mechanism of quantified saponins-rich fraction using target specific animal models. The anticonvulsant effect of quantified sa...

This study investigated the effect of green house conditions (temperature and soil moisture) on soybean [Glycine max (L.) Merr.] seeds bioactive compound concentrations. The analyses included plant characters and bioactive compounds contents. There were a good relationship between maturity date and total sphingolipids. Jack and Queen, among the latest and earliest had maturing entries, respecti...

A relatively simple and short procedure for the quantitative determination of gypsogenin saponins was performed to evaluate homeopathic tinctures in which those compounds can be regarded as one of the active constituents. This method comprises partial hydrolysis of saponins, subsequent extraction of liberated prosaponin (gypsogenin 3-O-glucuronide) and its analysis by high performance liquid ch...

Primula veris L. is an important medicinal plant with documented use for the treatment of gout, headache and migraine reaching back to the Middle Ages. Triterpenoid saponins from roots and flowers are used in up-to-date phytotherapeutic treatment of bronchitis and colds due to their expectorant and secretolytic effects. In addition to the wild type plants with yellow petals, a red variant and a...

Development of type 2 diabetes has been linked to β-cell failure coupled with insulin resistance and obesity. Adipose tissue, known as the fat store, secretes a number of hormones and proteins collectively termed adipokines some of which regulate insulin sensitivity. Dysregulation in the secretion of adipokines has been linked to insulin resistance and type 2 diabetes. In this review, we summar...

Ginseng, the famous plant drug, has been used as an expensive traditional medicine in oriental countries. The main ginseng plants of this drug are Panax ginseng C. A. MEYER, P. quinquefolium L. (American ginseng), P. natoginseng (Sanchi ginseng, or Tienchi ginseng), P. japonicus, and other species of Panax genus. One of physiological activity materials of ginseng plants is saponin (ginsenoside)...

Background: Hylomecon japonica, a plant of the Papaveraceae family which is well-known for the alkaloids they produce, is a perennial plant widely distributed in the northeast, central and east regions of China. Although a variety of chemical constituents, including alkaloids, flavonoids, and megastigmoids, have been isolated from H. japonica, the investigation of saponins in H. japonica has no...

Phytochemical study of the ethanol extract of the seeds of Aesculus chinensis led to the isolation of a new triterpenoid saponin (6), together with five known triterpenoid saponins (1-5). The structure of the new compound was elucidated on the basis of spectral data to be 21,28-di-O-acetylprotoaescigenin-3-O-[beta-D-glucopyranosyl(1-2)][beta-D-glucopyranosyl(1-4)]-beta-D-glucopyranosiduronic ac...

Soybeans (Glycine max L. Merill) and soy-based food products are major dietary sources of saponins. An oleanane triterpenoid saponin, soyasaponin Bh (1) containing a unique five-membered ring with a hemiacetal functionality together with seven known saponins were isolated from soybeans. Their structures were determined by chemical and spectroscopic analyses including HR-ESI-MS, 1D- and 2D-NMR. ...