Three glycosyltransferases have been identified in mammals that can initiate core 2 protein O glycosylation. Core 2 O-glycans are abundant among glycoproteins but, to date, few functions for these structures have been identified. To investigate the biological roles of core 2 O-glycans, we produced and characterized mice deficient in one or more of the three known glycosyltransferases that gener...

Changes in O-linked protein glycosylation are known to correlate with disease states but are difficult to monitor in a physiological setting because of a lack of experimental tools. Here, we report a technique for rapid profiling of O-linked glycoproteins in living animals by metabolic labeling with N-azidoacetylgalactosamine (GalNAz) followed by Staudinger ligation with phosphine probes. After...

Context. The formation of massive stars is not well-understood and requires detailed observational studies in order to discriminate between the different proposed star formation models. Aims. We have searched for massive molecular outflows in a sample of high-mass star forming regions, and we have characterised both the outflow properties and those of their associated molecular clumps. With a s...

We present an analysis of high resolution spectra in the far-UV − UV range (∼905-2000Å) with non-LTE, spherical, hydrodynamical, line-blanketed models, of three O-type Galactic stars, and derive their photospheric and wind parameters. These data extend previously analyzed samples and fill a gap in spectral type coverage. The combined sample confirms a revised (downward) Teff scale with respect ...

Background: Hepatitis is among the major health problems, especially in developing countries. During past decades, the association between type of blood group (ABO) and hepatitis B and C virus has always been discussed. This study was designed to investigate the possible association between type of ABO blood group and chronic hepatitis B and C infection. Methods: In the present analytical stud...

In the title compound, Na(3)(C(6)H(15)N(5)O)(2)[Al(OH)(6)Mo(6)O(18)](2)Cl·20H(2)O, the [Al(OH)(6)Mo(6)O(18)](3-) polyoxo-anion has a B-type Anderson structure exhibiting approximate D(3d) symmetry. There are two types of sodium cations: the Na(+) cations of type I have a distorted octa-hedral coordination geometry formed by six O atoms and are statistically distributed over two positions with e...

Thirty-six species o f wood-inhabiting microfungi have been assayed for cellulase, xylanase, mannanase and amylase activity by the use o f different test methods. The wood-degrading capabilities of the test organisms were previously known. Three o f the species were unable t o degrade birch wood. The other species represented three different degradation patterns, viz. I ) formation of soft rot ...

Plants were obtained with novel O(2)-resistant photosynthetic characteristics. At low CO(2) (250-350 muL CO(2) L(-1)) and 30 degrees C when O(2) was increased from 1% to 21% to 42%, the ratio of net CO(2) uptake in O(2)-resistant whole plants or leaf discs compared to wild type increased progressively, and this was not related to stomatal opening. Dihaploid plantlets regenerated from anther cul...

Type O units in the central nucleus of the inferior colliculus (ICC) of decerebrate cats are excited by best frequency (BF) tones near threshold, but are inhibited by high-level tones at all frequencies. Dorsal cochlear nucleus (DCN) principal cells display similar response map features and project directly to the ICC, and are thus supposed to be the dominant source of excitatory input for type...

Purpose To investigate the association between ABO blood types and clinicopathological characteristics in patients with prostate cancer (PC). Methods A total of 237 pathologically diagnosed PC patients were enrolled. All patients were classified as low-middle or high-risk group. The correlation of ABO blood types with high-risk PC was determined by univariate and multivariate regression analy...