Introduction: Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) are used in treating pathologic conditions such as fever, pain and inflammation by inhibiting cyclooxygenase and consequently prostaglandin production. Recently , the discovery of different isoforms of this enzyme, Cyclooxygenase-1 (COX-1) andCyclooxygense-2 (COX-2), has led to the synthesis and introduction of novel drugs with select...

We propose two positive parameters based on the choice of Birgin and Martínez search direction. Using classical choices Barzilai-Borwein parameters, were derived by minimizing distance between relative matrix corresponding to direction scaled memory-less Broyden–Fletcher–Goldfarb-Shanno (BFGS) in Frobenius norm. Moreover, resulting is descent independent any line condition. established global c...

We present the ghost-free infinite-derivative extensions of Spherically-Reduced Gravity (SRG) and Callan-Giddings-Harvey-Strominger (CGHS) theories in two space-time dimensions. For case SRG, we specify Schwarzschild-type gauge diagonalise quadratic action for field perturbations after taking background fields to be those flat-space solution with a linear dilaton. Using obtained diagonalisation...

In the present study, two new compositions of convergence order six are presented for solving nonlinear equations. The first method is obtained from third-order one given by Homeier using linear interpolation, and second Traub divided differences. requires three evaluations function evaluation derivative, thereby enhancing efficiency index. method, computation a derivative reduced approximating...

This paper presents the application of Sinc method to solve second order two-point boundary value problems based on derivative interpolation. Even in the presence of singularities, the Sinc numerical method is known to exhibit exponential convergence, resulting in highly accurate solutions. However, the customary approach of interpolating the solution variable with the Sinc bases requires first...