نتایج جستجو برای: tumor suppressor
تعداد نتایج: 445232 فیلتر نتایج به سال:
Nasopharyngeal carcinoma (NPC) is a malignant that appears in the epithelial lining of nasopharyngeal mucosa. Genetic predisposition, environmental risk factors, nutritional and Epstein-Barr virus (EBV) infection are main factors for NPC. virus, human cancer-associated present more than 90% people worldwide. Latent Membrane Protein 1 (LMP1) has been identified as converting oncoprotein. LMP1 wa...
The search for somatic mutations that drive the initiation and progression of human tumors has dominated recent cancer research. While much emphasis been placed on characterizing prevalence function driver mutations, comparatively less is known about their serial genetic evolution. Indeed, study this phenomenon largely focused tumor-suppressor genes recessive at cellular level or mechanisms res...
TP53 is the most commonly mutated tumor suppressor gene and its mutation drives tumorigenesis. Using ChIP-seq for p53 in the absence of acute cell stress, we found that wild-type but not mutant p53 binds and activates numerous tumor suppressor genes, including PTEN, STK11(LKB1), miR-34a, KDM6A(UTX), FOXO1, PHLDA3, and TNFRSF10B through consensus binding sites in enhancers and promoters. Depleti...
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