tumor progression

shahram torkamandi medical genetics research center, medical school, mashhad university of medical sciences, mashhad, iran meysam moghbeli division of human genetics, immunology research center, avicenna research institute, mashhad university of medical sciences, mashhad, iran moein farshchian department of biology, faculty of science, ferdowsi university of mashhad, mashhad, iran mohammad reza abbaszadegan medical genetics research center, medical school, mashhad university of medical sciences, mashhad, iran 2 division of human genetics, immunology research center, avicenna research institute, mashhad university of medical sciences, mashhad, iran

objective(s): epigenetic regulation of gene expression can be carried out through chromatin remodeling enzymes such as swi/snf. brg1 also known as smarca4 is a catalytic subunit of swi/snf, which is necessary for mmps expression. matrix metalloproteinases (mmps) are known as important player enzymes during tumor progression and metastasis. aberrant epigenetic modification of chromatin should be...

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The role of exosomes contents on genetic and epigenetic alterations of recipient cancer cells

Journal: Iranian Journal of Basic Medical Sciences 2016

Golnoush Dehbashi Behbahani, Hamideh Mahmoodzadeh Hosseini, Kazem Abbaszadeh-Goudarzi Saeed Nazeri, Soghra Khani,

Exosomes, as a mediator of cell-to-cell transfer of genetic information, act an important role in intercommunication between tumor cells and their niche including fibroblasts, endothelial cells, adipocytes and monocytes. Several studies have shown that tumor cells can influence their neighboring cells by releasing exosomes. These exosomes provide signaling cues for stimulation, activation, prol...

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