Crohn's disease (CD) is an idiopathic inflammatory disease of the gastrointestinal tract and typically causes inflammation with granuloma formation. Biologic agents like infliximab (IFX) that target tumor necrosis factor alpha (TNF-α), have emerged as important medications for treating refractory CD. With increasing use, there also are reports of rare but potentially fatal complications associa...

Objective: The development of neutralizing antibodies against infused factor VIII called inhibitor is the most challenging treatment complication in hemophilia A (HA) patients. Associated factors for are classified into 2 groups (genetics and non-genetics). Genetic other than mutation type F8 gene include family history, ethnical origin, human leucocyte antigen haplotype, a number polymorphisms...

background: low serum 25-hydroxy vitamin d (25(oh)d) has been shown to correlate with an increased risk of type 2 diabetes mellitus (t2dm). the objective of this study was to investigate the association between serum 25(oh)d and glycemic and inflammatory markers in non-obese patients with t2dm. methods: eighty-four non-obese patients with t2dm were recruited in this cross-sectional study. demog...

Despite that ataxia-telangiectasia mutated (ATM) is involved in IL-6 promoted lung cancer chemotherapeutic resistance and metastasis, the exact role of ATM in tumor necrosis factor-alpha (TNF-α) increasing tumor migration is still elusive. In the present study, we demonstrated that TNF-α promoted lung cancer cell migration by up-regulation of matrix metalloproteinase-13 (MMP-13). Notably, by ge...

Abstract Ocotea notata (Lauraceae) is popularly known as white-cinnamon. species have several medicinal uses, especially for treating chest pain, rheumatism and wounds. The present study aimed to analyze the chemical composition of O. n-hexane fraction, in addition its anti-mycobacterial immunomodulatory activities. fraction was analyzed by GC-MS chromatographed afford 15 subfractions (SF1-15),...

Limbal stem cell (LSC) deficiency is a frequent and severe complication after chemical injury to the eye. Previous studies have assumed this mediated directly by caustic agent. Here we show that LSC damage occurs through immune mediators, even without direct LSCs. In particular, pH elevation in anterior chamber (AC) causes acute uveal stress, release of inflammatory cytokines at basal limbal ti...

Activated T cells polarize mesenchymal stromal cells (MSCs) to a proinflammatory Th1 phenotype which likely has an important role in amplifying the immune response in the tumor microenvironment. We investigated the role of interferon gamma (IFN-γ) and tumor necrosis factor alpha (TNF-α), two factors produced by activated T cells, in MSC polarization. Gene expression and culture supernatant anal...

Objective Rofecoxib (Vioxx), the first COX-2 selective non-steroidal anti-inflammatory drug (NSAID), was recently withdrawn from the market due to the increased risk of acute myocardial infarction. The precise mechanism responsible for this phenomenon still remains unknown. Tumor necrosis factor alpha (TNF-α) is a cytokine, possibly most responsible for mortality in patients with acute myocardi...