Background Blockade of the PD-1 pathway is a therapeutic strategy to reinvigorate T cell responses against tumors, and when combined with other biologic therapies in first line setting this achieves significant clinical response about 25% hepatocellular carcinoma (HCC) patients. We hypothesize that phenotypic diversity tumor infiltrating cells can explain, at least partially, disparate immunoth...

objectives this study aimed at reviewing the current literature on the diagnosis, staging, and different treatment strategies for wilms’ tumor with either ureteral or intravascular extension. evidence acquisition in this article, we reviewed the current literature about staging, diagnosis, and management strategies for wt, through a randomized clinical trial, which focused on this matter. the m...

calcifying fibrous tumor (cft) is a rare mesenchymal tumor, affecting children and young adults with a predilection for the soft tissue and the abdominal cavity. cft of the tubular gastrointestinal tract is very rare with less than 20 cases of gastric cfts reported in english literature. this benign hypocellular fibrosclerotic calcifying lesion can resemble other spindle cell tumors particularl...

purpose : to review periocular dermoid cysts to determine distribution of demographic factors, and tumor location methods : in this retrospective, observational case series in a tertiary-care hospital, we reviewed all cases of histopathologically verified periocular dermoid cysts at our institution between 2003 and 2011. the study endpoints included: age, gender, and tumor location. results : t...

Background: Limitations with agents that activate endogenous T cell responses to cancer, particularly in the setting of solid tumors, supports study alternative mechanisms. STAR0602 is a bifunctional antibody—fusion molecule selectively activates and expands sub—set human aβ cells expressing germline—encoded variable b6 b10 regions receptor (TCR). simultaneously engages novel, direct TCR activa...