background: androgen receptors (ar) play an important role in proliferation of cancerous prostatic cells and prevention of apoptotic signaling. current drugs cannot inhibit the activity of these receptors very well. establishment of appropriate animal models is essential for discovery of new drugs of target therapy in hormone dependent prostate cancer. materials and methods: standard prostatic ...

background and objectives: achillea is an ancient medicinal herb. the genus comprises about 100 species which are mostly distributed in northern hemisphere and some have been investigated for different biological activities. there are also several reports in iranian traditional medicine (itm) texts about its anti-tumor effect. the cytotoxic activity of the methanol extract of achillea vermicula...

the cytotoxic activity of ethanolic extracts of thymus vulgaris, thuja orientalis and achillea millefolium was investigated on various growing tumor cell lines. mtt colorimetric assay was used for measuring the inhibition of cell proliferation. all of the three extracts showed a relatively dose-dependent inhibition of proliferation of human breast cancer (sk-br-3, mda-mb-435) and leukemia (u937...

peganum harmala l. (zygophyllaceae) is one of the most important medicinal plants had been used in traditional medicine in north of iran as anti parasite, anti inflammatiom, anti tumor and anti infection. the aim of this study was to evaluate of ecological factors , ethno pharmacology and record of the relationship between secondary metabolites content and their antioxidant activity in seeds ex...

Cancer stem cells (CSCs) are the in a primary tumor that have opportunity to self-renew as well differentiate into certain cell types, thus forming mixed tumor. CSCs been shown be involved every aspect of cancer development, including initiation, proliferation, and metastatic activity; they also chemotherapeutic drug resistance recurrence cancers. Based on these capabilities, explored next targ...