Abstract Objective We examined the clinical manifestations of acute encephalopathy (AE) and identify risk factors for AE in children with tuberous sclerosis complex (TSC). Methods The data 11 clinically diagnosed TSC associated 109 alone aged 4 years or older were collected from 13 hospitals. Results Of AE, 5 had histories febrile seizures (FS), all status epilepticus (FSE). developed within 24...