In certain applications the use of stable compensators greatly simplifies controller testing and implementation. Unfortunately, standard LQG theory, as well as mixednorm H2/H, theory, may yield compensators that are unstable. The problem of synthesizing stable stabilizing controllers has been of interest for many years [14], and a variety of techniques have been proposed based on modifications ...

BACKGROUND AND PURPOSE There are few articles characterizing cerebellar lesions in patients with TSC and no published series documenting longitudinal evaluation of these lesions, to our knowledge. Recent suggestion of a correlation between autism and cerebellar lesions in patients with TSC heightens the importance of understanding these lesions. Our purpose was to characterize cerebellar lesion...

Traditionally, an anti-windup compensator is activated when control signal saturation occurs. An alternative approach is to activate the compensator at a level below that of the physical control constraints: the antiwindup compensator is activated in anticipation of actuator saturation. Recent studies have proposed systematic methods for the construction of such anticipatory anti-windup compens...

Background: Graph theory has been recently introduced to characterize complex brain networks, making it highly suitable to investigate altered connectivity in neurologic disorders. A current model proposes autism spectrum disorder (ASD) as a developmental disconnection syndrome, supported by converging evidence in both non-syndromic and syndromic ASD. However, the effects of abnormal connectivi...

In mice that express SOD1 mutations found in human motor neuron disease, degeneration begins in the periphery for reasons that remain unknown. At the neuromuscular junction (NMJ), terminal Schwann cells (TSCs) have an intimate relationship with motor terminals and are believed to help maintain the integrity of the motor terminal. Recent evidence indicates that TSCs in some SOD1 mice exhibit abn...

PURPOSE To describe two patients with macular oedema secondary to tuberous sclerosis complex (TSC) who were treated with intravitreal bevacizumab injection. METHODS Interventional case reports. Bevacizumab 1.25 mg was injected into the vitreous of two patients with TSC-associated macular oedema / exudative retinal detachment. Vascular endothelial growth factor (VEGF) concentration in the vitr...

Tuberous Sclerosis Complex (TSC) is a genetic disease causing uncontrolled growth of hamartomas involving different organ systems. In the last decade, dysregulation of the mTORC1 pathway was shown to be a main driver of tumor growth in TSC. Recently, a new crosstalk was detected between the mTORC1 and the Hippo-YAP pathway, another major cell signaling cascade controlling cell growth and organ ...

Double scattering-based proton therapy systems often use patient-specific range compensators for beam modulation. Range compensators adjust the depth in the tissue at which protons reach their Bragg peak. Accurately representing range compensators in Monte Carlo particle transport simulations is a vitally important problem for clinical treatment planning. This paper proposes two new computation...

BACKGROUND Neuropsychiatric disorders are present in up to 90% of patients with Tuberous Sclerosis Complex (TSC), and represent an important issue for families. Autism Spectrum Disorder (ASD) is the most common neurobehavioral disease, affecting up to 61% of patients. The aims of this study were: 1) to assess the prevalence of ASD in a TSC population; 2) to describe the severity of ASD; 3) to i...