sequence method TS (%) BDPSNR (dB) BDBR (%) QP=16 QP=20 QP=24 QP=28 mobile qcif Jlee 2.0 6.6 14.4 28.1 -0.02 0.28 our 31.9 32.1 34.2 39.6 -0.04 0.70 hall qcif Jlee 2.0 5.3 28.4 43.5 0.00 -0.01 our 39.4 42.3 45.5 47.9 -0.03 0.94 container cif Jlee 8.1 39.7 48.1 53.9 0.03 -0.76 our 49.3 52.3 53.8 55.5 0.03 -0.79 coastguard cif Jlee 1.3 4.5 13.1 24.6 -0.02 0.30 our 31.3 30.6 32.1 34.4 -0.05 0.86 m...

BACKGROUND Previous small-sized studies showed lower thymidylate synthase (TS) expression in adenocarcinoma of the lung, which may explain higher antitumor activity of TS-inhibiting agents such as pemetrexed. PATIENTS AND METHODS To quantitatively measure TS gene expression in a large-scale Japanese population (n = 2621) with primary lung cancer, laser-captured microdissected sections were cu...

Sir Short stature is a cardinal feature of Turner syndrome. We examined height outcome and its relation to growth hormone therapy in Irish girls with Turner syndrome. In those with Turner syndrome (TS), the adult stature is an average 20 cm shorter than the general population 1 . By 15 years of age, the average height of an untreated girl with TS is equivalent to that of only a 9.5-year-old gir...

Mouse FM3A mammary adenocarcinoma cells exposed to the specific thymidylate synthetase (TS) inhibitor 10-propargyl-5,8-dideazafolate (PDF) responded by overproducing TS up to 200-fold. In the absence of inhibitor, the elevation of TS levels decayed with a half-life of about 4 weeks. Southern blot analysis of restricted DNA from the PDF-resistant cells using a TS-specific probe showed that the T...

A hydroponic experiment was conducted in the present study to investigate and compare plant uptake, translocation and metabolism of polybrominated diphenyl ethers (PBDEs) of BDE-15, BDE-28 and BDE-47 and polychlorinated biphenyls (PCBs) of PCB-15, PCB-28 and PCB-47 in maize. Root concentrations of BDE-15, BDE-28 and BDE-47 were consistently higher than PCB-15, PCB-28 and PCB-47, respectively. A...

This study aims to design some dual-target anticancer candidates, capable to act as an alkylating agent as well as a thymidylate synthase (TS) inhibitor. The designed scaffold is a combination of nucleobase, amino acid and aziridine structures. The candidates are docked into TS and three DNA double strand structures and evaluated based on their binding interaction energies and ligand efficienci...