Transcriptional regulatory network (TRN) reconstitution and deconstruction occur simultaneously during reprogramming; however, it remains unclear how the starting and targeting TRNs regulate the induction and suppression of peripheral genes. Here we analyzed the regulation using direct cell reprogramming from human dermal fibroblasts to monocytes as the platform. We simultaneously deconstructed...

BACKGROUND The Anambra state Malaria Control Booster Project (ANMCBP) depends on an effective monitoring and evaluation (M&E) system to continuously improve the implementation of the malaria control interventions. However, it is not clear how the health workers that are expected to be the fulcrum of the malaria M&E perceive and practise M&E. The study was carried out to determine the knowledge,...

Friction stir welding (FSW) is the solid state technique which mostly utilized to join similar and dissimilar Al, Cu, Mg, their alloys. This research investigated that tensile strength of FSW Al6262 Al5456 4 mm thickness carried out using an H-13 tool pin along with different process variables such as rotational speed (TRS), (WS), tilt angle (TTA). The selected parameters are set TRS 900, 1100,...

NS-398 [N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide], a selective inhibitor of cyclooxygenase-2 (COX-2), inhibited proliferation induced by platelet-derived growth factor (PDGF) in Swiss 3T3 fibroblasts. The effect of NS-398 was found to be concentration-dependent. The half-maximal effect occurred at approximately 0.1 microM. NS-398 decreased mitogenesis at subsaturating PDGF concentrat...

This paper presents early results of a (very) experimental implementation of the elliptic curve and stream cipher calculations of the Networking and Cryptography library (NaCl), on the TRS-80 Model I. Needless to say, the demonstration that such a library, which has been optimized for many modern platforms including leading edge desktops, servers and, recently, modern microcontrollers, is even ...

Bernstein et al. have proposed a new permutation,Gimli [1], which aims to provide simple and performant implementations on a wide variety of platforms ranging from the AVR ATmega and ARM-Cortex to the Intel Haswell. In a festive spirit of retrocomputing, this brief paper reports such a simple and (somewhat) performant implementation on the almost Third-Age-of-Middle-earth-dating TRS-80.

Solving the trust-region subproblem (TRS) plays a key role in numerical optimization and many other applications. The generalized Lanczos (GLTR) method is well-known type approach for solving large-scale TRS. projects original TRS onto sequence of lower dimensional Krylov subspaces, whose orthonormal bases are generated by symmetric process, computes approximate solutions from underlying subspa...

In this paper we define and study intersection type assignment systems for first-order rewriting extended with application, λ-abstraction, and β-reduction (TRS+β). One of the main results presented is that, using a suitable notion of approximation of terms, any typeable term of a TRS+β that satisfies a general scheme for recursive definitions has an approximant of the same type. From this resul...