This study examined the dynamics of muscle oxygenation during exercise between chronic obstructive pulmonary disease (COPD) patients and age-matched healthy controls. Oxygen saturation of the vastus lateralis muscle (SmO2) was measured during incremental cycle exercise in 11 patients with exercise intolerance below the anaerobic threshold (AT) workload (COPD-AT(-)), 11 patients with exercise in...

While prophylaxis with factor VIII (FVIII) is considered the first choice therapy for patients with severe haemophilia A the optimal prophylaxis regimen is still under scientific debate. A recent study demonstrated efficacy and safety of a PK-tailored prophylaxis regimen with rFVIII (ADVATE) aimed to maintain FVIII trough levels of ≥1% (19). The annual bleed rate (ABR) could be significantly re...

PURPOSE Imatinib minimal (trough) plasma concentrations after one month of treatment have shown a significant association with clinical benefit in patients with gastrointestinal stromal tumors (GIST). Considering that a retrospective pharmacokinetic analysis has also suggested that imatinib clearance increases over time in patients with soft tissue sarcoma and GIST, the primary aim of this stud...

OBJECTIVE To compare five published nomograms (Thomson guidelines, Mawer nomogram, rule of eights, Hull-Sarubbi table and Dettli method) for calculating the initial gentamicin dosage regimen in a Kuwaiti population. MATERIALS AND METHODS Based on measured peak and trough gentamicin concentrations, the elimination rate constant and volume of distribution of gentamicin were calculated for each ...

AIMS The aim of the present study was to demonstrate evidence of reduced thrombin generation at the trough plasma rivaroxaban concentration. METHODS A single-centre, prospective, nonrandomized, drug-intervention, self-controlled study was conducted in 51 anticoagulation therapy-naïve patients with nonvalvular atrial fibrillation. Plasma rivaroxaban concentration was measured by liquid chromat...

OBJECTIVES The aim of this study was to evaluate the correlation between liver function markers (necrosis and cholestasis) and plasma lopinavir levels in a cohort of HIV-infected patients treated with lopinavir and ritonavir. PATIENTS AND METHODS The blood samples for determining steady-state C(trough) lopinavir levels and analysing liver function were drawn from fasting patients. Steady-stat...

conclusions the result of this study indicated that nephrotoxicity rate among patients treated with vancomycin is under the influence of the poisoning by nephrotoxicants. higher vancomycin trough level was associated with increasing nephrotoxicity rate. results one hundred and fifty-four vap patients’ profiles were reviewed, of whom 110 were eligible. the median age was 33.50 (12 to 94) years a...

Although ionospheric troughs are a very important feature of the subauroral ionosphere, many of their properties remain incompletely documented and understood. Here Dynamics Explorer-2 satellite data are used to investigate one specific part of this complex phenomenon, namely its equatorward wall. We find that in the afternoon/evening sector of the Northern Hemisphere the location of this densi...

BACKGROUND Lymphangioleiomyomatosis (LAM) is a rare disease caused by dysregulated activation of the mammalian target of rapamycin (mTOR). Sirolimus, an inhibitor of mTOR, has been reported to decrease the size of angiomyolipomas and stabilize pulmonary function in patients with LAM. However, the optimal dose for the treatment of LAM remains unclear. METHODS We conducted a retrospective, obse...