BACKGROUND Placenta accreta is a rare obstetric condition but can lead to life-threatening complications that was mainly diagnosed in the third trimester. We present a case of acute trophoblastic pulmonary embolism (PE) during conservative treatment of placenta accreta. CASE PRESENTATION A 24-year-old patient who delivered vaginally at 40(+4) weeks gestation. The placenta was retained despite...

Serum levels for beta-human chorionic gonadotropin (beta-hCG) and pregnancy-specific beta 1-glycoprotein (SP1) in patients with trophoblastic disease were measured by radioimmunoassay and enzyme-linked immunosorbent assay. The beta-hCG:SP1 ratios were below 1.0 in all 22 cases of complete hydatidiform mole and in 8 of 9 cases of partial hydatidiform mole. Two (10.5%) of 19 cases of invasive mol...

A human hormone-synthesizing trophoblastic cell system has been established in vitro and may prove to be the first func tional human embryonic cell line in continuous culture. Chorionic gonadotropin hormone produced by these cultures serve as a marker for identification of the trophoblastic cell. No interruption in this property nor change in cytologie display has occurred during 1.5 years in c...

Human trophoblastic cells (T3M-3) metabolized 25-hydroxyvitamin D3 into two more polar metabolites during in vitro incubations. A two-step high pressure liquid chromatography system revealed two unique elution positions of those trophoblastic cell-derived metabolites that exactly co-migrated with the elution positions of 5(Z)-19-nor-10-oxo-25-hydroxyvitamin D3 and 5(E)-19-nor-10-oxo-25-hydroxyv...

A human hormone-synthesizing trophoblastic cell system has been established in vitro and may prove to be the first func tional human embryonic cell line in continuous culture. Chorionic gonadotropin hormone produced by these cultures serve as a marker for identification of the trophoblastic cell. No interruption in this property nor change in cytologie display has occurred during 1.5 years in c...

The reported incidence of gestational trophoblastic disease is 1-2:1000 pregnancies. The disease includes a) hydatidiform mole (partial and complete), b) invasive mole, c) choriocarcinoma and d) placental site trophoblastic tumors. Current management is based on several prognostic risk factors. We describe an interesting case of a 51-year–old woman who presented with abnormal vaginal bleeding a...

Chorangiocarcinoma is an extremely rare primary placental neoplasm, with only five cases reported in the literature (Table 1). Some researchers considered it as a bona fide chorangiocarcinoma, but most cases described a chorangioma with abnormal trophoblastic proliferation. In spite of atypia in cytology, marked mitosis and tumor necrosis, chorangiocarcinoma was always reported benign. No metas...

placental site trophoblastic tumor (pstt) is a very rare variant of gestational trophoblastic tumor. it can occur after normal termination of pregnancy or spontaneous abortion and ectopic or molar pregnancy. there is a wide range of clinical manifestations from a benign condition to an aggressive disease with fatal outcome. one of the most important characteristics of pstt, unlike other forms o...

We describe a case of choriocarcinoma in which increased concentrations of beta-choriogonadotropin subunits in serum indicated recurrence of metastasis long before the tumor could be confirmed by visualization techniques, while intact choriogonadotropin remained normal (less than 5 int. units/L). Therefore, detection or monitoring of choriocarcinoma requires the assay of free beta-hCG subunit o...

Placental site trophoblastic tumor is a very rare variant of gestational trophoblastic disease which differs histologically and immunocytochemically from gestational choriocarcinoma. The English language literature includes only 74 reported cases. Seventeen patients have been managed at Charing Cross Hospital with this diagnosis. The median follow-up is 4.6 years, and the 5-year overall surviva...