نتایج جستجو برای: triplication
تعداد نتایج: 451 فیلتر نتایج به سال:
Field-programmable gate arrays (FPGAs) are often utilized in space avionics. To protect the FPGA logic against the ionizing radiation effects in space, redundancy in form of concurrent error detection can be used. In this work, we present a comparative study of a parity-based error detection with software-based retry, and a triple modular redundancy technique on a known flash-based FPGA archite...
Down syndrome (DS) arises from triplication of genes on human chromosome 21 and is associated with anomalies in brain development such as reduced production of neurons and increased generation of astrocytes. Here, we show that differentiation of cortical progenitor cells into astrocytes is promoted by DYRK1A, a Ser/Thr kinase encoded on human chromosome 21. In the Ts1Cje mouse model of DS, incr...
G protein-activated inwardly rectifying K+ channels (GIRK) generate slow inhibitory postsynaptic potentials in the brain via G(i/o) protein-coupled receptors. GIRK2, a GIRK subunit, is widely abundant in the brain and has been implicated in various functions and pathologies, such as learning and memory, reward, motor coordination, and Down syndrome. Down syndrome, the most prevalent cause of me...
in order to evaluate the microvascular anatomy and the interconnections, 101 fixed brains from human cadavers with a mean age of 41.3 years were subjected to objective scrutiny. symmetry was visualized with an unaided eye and measurements made under microscopic magnification technique using a micrometer. classic symmetry was observed in only 19 of the specimens, whereas the rest of the 82 speci...
Loss of function of the X-linked gene encoding methyl-CpG binding protein 2 (MeCP2) causes the progressive neurological disorder Rett syndrome (RTT). Conversely, duplication or triplication of Xq28 causes an equally wide-ranging progressive neurological disorder, MECP2 duplication syndrome, whose features overlap somewhat with RTT. To understand which MeCP2 functions cause toxicity in the dupli...
SH signals recorded by an array of four broadband (Benioff 1-90) instruments, run by Caltech, are inspected for evidence of a lower mantle shear wave velocity discontinuity previously detected using WWSSN data. Deep focus earthquakes beneath Argentina span the distance range 78 ø to 82 ø from the array, where the triplication in the travel time curve produced by the discontinuity is expected to...
The Linked Data best practices recommend publishers of triplesets to use well-known ontologies in the triplication process and to link their triplesets with other triplesets. However, despite the fact that extensive lists of open ontologies and triplesets are available, most publishers typically do not adopt those ontologies and link their triplesets only with popular ones, such as DBpedia and ...
Coffee is a valuable beverage crop due to its characteristic flavor, aroma, and the stimulating effects of caffeine. We generated a high-quality draft genome of the species Coffea canephora, which displays a conserved chromosomal gene order among asterid angiosperms. Although it shows no sign of the whole-genome triplication identified in Solanaceae species such as tomato, the genome includes s...
The group-specific component (Gc) is the major vitamin D-binding protein in plasma. The gene encoding Gc is linked, on human chromosome 4, to the albumin and alpha-fetoprotein genes. These two genes previously were shown to have evolved from a smaller ancestral gene by intragenic triplication. Recombinant plasmids containing human cDNA encoding Gc have been isolated by screening an adult human ...
From a tandem duplication mutant of phage P2, triplication, quadruplication and pentuplication forms were derived. They were recognized by decreased virion heat stability resulting from the increase in DNA content, and were confirmed by electron microscope heteroduplex mapping. These forms of partially repeated DNA are quite stable in P2 because of the low level of recombination typical of this...
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