BACKGROUND  The regimen of linezolid and moxifloxacin was found to be efficacious in the hollow fiber system model of pediatric intracellular tuberculosis. However, its kill rate was slower than the standard 3-drug regimen of isoniazid, rifampin, and pyrazinamide. We wanted to examine the effect of adding a third oral agent, faropenem, to this dual combination. METHODS  We performed a series ...

BACKGROUND/AIMS One-week triple therapy has been recommended as a standard regimen for eradicating Helicobacter pylori infection. The emergence of antibiotic-resistant strains, adverse drug effects, poor compliance and high cost of therapy add problems to the management of these patients. In this study, we assessed whether a 3-day triple therapy could be effective in eradicating Helicobacter py...

background helicobacter pylori (h. pylori) is one of the most common bacterial infections worldwide. we designed a study to compare the efficacy of 14-day hybrid regimen with 10-day concomitant therapy for h. pylori eradication in iran. methods 252 patients with naïve h. pylori infection were randomly divided to receive either hybrid regimen (pantoprazole 40 mg, and amoxicillin 1 gr twice daily...

According to the Maastricht VI consensus, triple therapy (PPI + clarithromycin amoxicillin) and bismuth-based quadruple bismuth tetracycline metronidazole) are considered may be proscribed empirically as first-line regimens in regions with low resistance rates (<15%). In high (> 15%), well unknown this antibacterial agent, it is recommended use classical drugs main choice without (“simult...

Helicobacter pylori (H. pylori) treatment remains a challenge for the clinician, as no available therapy is able to cure the infection in all treated patients. In the last two decades, several antibiotic combinations have been proposed, including triple therapies, bismuth-free therapies (sequential, concomitant, hybrid regimens), and bismuth-based quadruple therapy. Some national and internatio...

De Gascun and colleagues report on a case of methicillinsusceptible Staphylococcus aureus (MSSA) sepsis treated successfully with linezolid after initial failure of a triple regimen of apparently appropriate antibiotics. They ascribe the observed efficacy of linezolid to an anti-toxin effect of the antibiotic. Linezolid acts by inhibiting bacterial protein synthesis, and it, therefore, blocks t...

Cyclosporine (CsA) is the current primary immunosuppressant for the prevention of renal allograft rejection. Its chronic use is associated with various adverse effects like hypertension, hyperlipidemia, and nephrotoxicity, which in turn may contribute to chronic allograft nephropathy and cardiovascular mortality. This study compares a CsA-free maintenance regimen of mycophenolate mofetil (MMF) ...