The multidomain protein Trio regulates among others neuronal outgrowth and axonal guidance in vertebrates and invertebrates. Trio contains two Dbl-homology/pleckstrin homology (DH/PH) tandem domains that activate several RhoGTPases. Here, we present the x-ray structure of the N-terminal DH/PH, hereafter TrioN, refined to 1.7-A resolution. We show that the relative orientations of the DH and PH ...

FilaminC (FLNc) is the muscle-specific member of a family of actin binding proteins. Although it interacts with many proteins involved in muscular dystrophies, its unique role in muscle is poorly understood. To address this, two models were developed. First, FLNc expression was stably reduced in C2C12 myoblasts by RNA interference. While these cells start differentiation normally, they display ...

Recent advances in technology have suggested that sound and audio play a far greater part in our daily working lives than ever before. Mobile phone ring tones are now based upon polyphonic music sequences that allow relatively complex audio to be generated from a handset by way of conveying information (i.e. a call or message is incoming). This real world example of sonification suggests that f...

We report trio upconversion laser action in Er:LiYF(4) with excitation at 1.55 microm resulting in cw emission at 0.55 microm to a temperature of 95 K and contrast its performance with earlier green erbium upconversion lasers.

A trio of papers has resolved an outstanding controversy regarding the function of Merkel cells and their afferent nerve fiber partners. Merkel cells sense mechanical stimuli (through Piezo2), fire action potentials, and are sufficient to activate downstream sensory neurons.

This article focuses on the analysis of selected phenomena related to work, consumption and happiness. The thesis was formulated that tendency equate happiness with possession goods has an impact social life, as well individual’s life work. Increasingly glorifying ethos a factor development enrichment, formula is distorted its correlates are neglected.