Cyanide forms an inhibitory complex with the haem d-containing E. coli catalase HPII, spectrally similar to the cyanide complex of beef liver enzyme but with absorption bands shifted 90 nm towards the red end of the spectrum. Both the Kd and Ki values are approximately 7 microM in the wild-type enzyme. The cyanide reaction is slow, with a bimolecular 'on' constant approx. 2000 x smaller than th...

We describe the syntheses, solid-state structures, and magnetic properties of lanthanide(III)-tris(bis(heterocyclo)methanides) [(THF)M{(NCOC6H4)2CH}3], with M=Tb (1), Dy (2), Ho (3), Er (4), respectively. The corresponding lanthanide bis(trimethylsilyl)amides have been prepared as starting materials to deprotonate neutral bis(benzoxazol-2-yl)methane ({NCOC6H4}2CH2) at central methylene bridge g...

Addition of Potassium cyanide to a mixture of Schiff base and lithium perchlorate afforded a-aminonitriles in high yields. Addition of potassium cyanide to a methanolic solution of Schiff base and phosphoric acid afforded a-aminonitriles. When the reaction mixture was refluxed it gave a-amino acids in high yields.

Cyanide causes toxic effects by inhibiting cytochrome c oxidase, resulting in cellular hypoxia and cytotoxic anoxia, and can eventually lead to death. Cyanide exposure can be verified by direct analysis of cyanide concentrations or analyzing its metabolites, including thiocyanate (SCN(-)) and 2-amino-2-thiazoline-4-carboxylic acid (ATCA) in blood. To determine the behavior of these markers foll...

Cyanide is a competitive inhibitor of carbon dioxide in the vitamin K-dependent glutamate carboxylase system, which plays a central role in the function of the blood clotting cascade. The mechanism of cyanide inhibition has been obscure for some time. At pH 7.2, cyanide (pKa = 9.21) will exist in solution as hydrogen cyanide to the extent of 99%. Hydrogen cyanide is linear triatomic molecule ab...

A Rhodococcus sp. UKMP-5M isolate was shown to detoxify cyanide successfully, suggesting the presence of an intrinsic property in the bacterium which required no prior cyanide exposure for induction of this property. However, in order to promote growth, Rhodococcus sp. UKMP-5M was fully acclimatized to cyanide after 7 successive subcultures in 0.1 mM KCN for 30 days. To further shorten the lag ...

Cyanide is a species of high toxicity that found mostly in industrial effluents such as electroplating, metal mining, metallurgy and metal cleaning processes. Entrance of it to existence environment contains very health hazardous. Objective of this study was the determination of efficiency of sonochemical technology for cyanide removal from aqueous solutions. In this study, it has been used fro...

Novel neutral glycosphingolipids isolated from the plerocercoids of a tapeworm, Spirometra erinacei, may be expected to be involved in host-parasite interactions. We have synthesized this glycosphingolipid analogue containing 2-branched fatty alkyl residue in place of ceramide. Glycosylation of nonreducing-end trisaccharide derivative 15 with the reducing-end disaccharide derivative 17 in the p...

An improved method for a suitable derivatization of polyhydroxylated steroids having one or two tert-hydroxyl groups at the 5beta-, 14alpha-, 17alpha-, 24-, and/or 25-positions by capillary gas chromatography (CGC) is described. By using trimethylsilyl triflate as a silylating reagent and 2,6-lutidine as a catalyst, each of 5beta-cholane and 5alpha-cholestane series of steroids was successfully...

Two new molecular structures, namely 1,3-bis(trimethylsilyl)-1H-benzimidazole-2(3H)-thione, C13H22N2SSi2, (2), and 1-trimethylsilyl-1H-benzimidazole-2(3H)-thione, C10H14N2SSi, (3), are reported. Both systems were derived from 1H-benzimidazole-2(3H)-thione. Noncovalent C-H···π interactions between the centroid of the benzmidazole system and the SiMe3 groups form helicoidal arrangements in (2). D...