Over 4.5 billion people are at risk of infection with soil transmitted helminths and there are concerns about the development of resistance to the handful of frontline nematocides in endemic populations. We investigated the anti-nematode efficacy of a series of polypyridylruthenium(II) complexes and showed they were active against L3 and adult stages of Trichuris muris, the rodent homologue of ...

Background: Infections with soil-transmitted helminths (STHs) predominantly affect impoverished populations in tropical environments. The periodic administration of single dose benzimidazoles (i.e., albendazole, mebendazole) to at-risk individuals endemic regions is at the center STH control strategies. Given low efficacy these drugs against trichuriasis, investigati...

BACKGROUND Robust reference values for fecal egg count reduction (FECR) rates of the most widely used anthelmintic drugs in preventive chemotherapy (PC) programs for controlling soil-transmitted helminths (STHs; Ascaris lumbricoides, Trichuris trichiura, and hookworm) are still lacking. However, they are urgently needed to ensure detection of reduced efficacies that are predicted to occur due t...

BACKGROUND Sensitive diagnostic tools are required for an accurate assessment of prevalence and intensity of helminth infections in areas undergoing regular deworming, and for monitoring anthelmintic drug efficacy. We compared the diagnostic accuracy of the Kato-Katz and FLOTAC techniques in the frame of a drug efficacy trial. METHODOLOGY/PRINCIPAL FINDINGS Stool samples from 343 Zanzibari ch...

BACKGROUND The intestinal nematode Trichuris trichiura is among the most common causes of human infectious disease worldwide. As for other soil-transmitted nematodes, its reproductive success and thus prevalence and intensity of infection in a given area strongly depend on environmental conditions. Characterization of the influence of environmental factors can therefore aid to identify infectio...

during 1979-77 a large number of kurdish populations in northern part of iraq temporarily immigrated to iran and settled in dezful area of khuzestan province, south-west iran. faecal examination of 3,263 samples for intestinal metazoan parasites and 1,154 urine samples for detecting schistosoma haematobium, infection were performed in different sex and age groups. the percentages of prevalent i...

INTRODUCTION Soil-transmitted helminth (STH) infections are predominately controlled by providing children with preventive chemotherapy with either albendazole or mebendazole. However, neither has a high efficacy against Trichuris trichiura. This low efficacy limits the overall effectiveness of the current STH control programmes against T. trichiura. It has been demonstrated that co-administeri...

BACKGROUND Kato-Katz is a widely used method for the diagnosis of soil-transmitted helminth infection. Fecal samples cannot be preserved, and hence, should be processed on the day of collection and examined under a microscope within 60 min of slide preparation. Mini-FLOTAC is a technique that allows examining fixed fecal samples. We assessed the performance of Mini-FLOTAC using formalin-fixed s...

BACKGROUND The control of soil-transmitted helminth (STH) infections currently relies on the large-scale administration of single-dose oral albendazole or mebendazole. However, these treatment regimens have limited efficacy against hookworm and Trichuris trichiura in terms of cure rates (CR), whereas fecal egg reduction rates (ERR) are generally high for all common STH species. We compared the ...

Abstract. Setyowati EA, Santoso S, Rokhmani, Rochmatino. 2022. Diversity and prevalence of endoparasites in domestic chickens across an elevation gradient. Biodiversitas 23: 3936-3942. The chicken farm is negatively affected by endoparasites, which decrease immunity, egg production, body weight. Although these effects are well understood large-scale farms, here we aimed to understand endoparasi...