Understanding drug transportation mechanisms in the human body is of paramount importance in modeling Pharmacokinetic-Pharmacodynamic relationships. This work gives a novel general model of efavirenz transportation projections based on concentrations simulated from patients on a dose of 600 mg. The work puts forward a proposition that transportation can wholly be modeled by concentration and ti...

Over the past two decades, maritime transportation and container traffic worldwide has experienced rapid and continuous growth. With the increase in maritime transportation volume, the issue of greenhouse gas (GHG) emission has become one of the new concerns for port managers. Port managers and government agencies for sustainable development of maritime transportation considered "green ports" t...

Global warming is likely one of the most serious and urgent issues facing the U.S. transportation sector. Major reductions in greenhouse gas emissions from the transportation sector will be needed in order to stabilize the climate and avoid the most serious effects of global warming. Travel models can play an important role in evaluating potential policies for reducing transportation sector gre...

Motivated by a planned automated cargo transportation network, we consider transportation problems in which the finite capacity of resources has to be taken into account. We present a flexible modeling methodology which allows to construct, evaluate, and improve feasible solutions. The modeling is evaluated on instances stemming from a simulation model of the planned cargo transportation system.

Agent technology is a software paradigm that permits to implement large and complex distributed applications. In order to assist the development of multi-agent systems, agent-oriented methodologies (AOM) have been created in the last years to support modeling more and more complex applications in many different domains. By defining in a non-ambiguous way concepts used in a specific domain, Meta...

Two contrasting attributes of transportation costs are introduced in this analysis. These are categorized as internal and external to the firm or the industry. It is shown that the trade-off interaction between agglomeration economies and transportation costs in established location theory solely refers to the external nature of transportation costs to the firm. This paper reveals that there is...

This study discusses a decision support framework that guides policy makers in their strategic transportation related decisions by using multi-methodology. For this purpose, a methodology for analyzing the effects of transportation policies on environment, society, economy, and energy is proposed. In the proposed methodology, a three-stage problem structuring model is developed. Initially, expe...

in order to improve the level of intelligence, availability, being on demand, convenience, information and humanization of rural public transportation systems, they are more willing to use modern information and communicative technologies. in addition to management services, intelligent transportation systems can provide passengers, drivers, travel agencies and other institutions with other ser...

This paper focuses on generating the optimal solutions of the solid transportation problem under fuzzy environment, in which the supply capacities, demands and transportation capacities are supposed to be type-2 fuzzy variables due to the instinctive imprecision. In order to model the problem within the framework of the credibility optimization, three types of new defuzzification criteria, i.e....

Optimization plays an important role in most real world applications that support decision makers to take the right decision regarding the strategic directions and operations of the system they manage. Solutions for traffic management and traffic congestion problems are considered major problems that most decision making authorities for cities around the world are looking for. This review paper...