We studied 24 recipients of autologous bone marrow transplantation (ABMT) or allogeneic BMT (BMT) to determine whether impaired erythropoietin (Epo) response to anemia could delay full erythropoietic recovery. Observed Epo levels were compared with predicted levels based on the relationship between Epo and hematocrit in 125 control subjects. Circulating Epo levels were normal during conditionin...

MPS VI1 mice are deficient in P-glucuronidase and share many clinical, biochemical, and pathologic characteristics with human mucopolysaccharidosis type VI1 (MPS VII). We have shown that syngeneic bone marrow transplantation (BMT) prolongs survival and reduces lysosomal storage in many organs of the MPS VI1 mouse. In this report, we quantify the hearing loss and determine the impact of syngenei...

Bone marrow transplantation (BMT) is commonly used to study the participation of bone marrow–derived cells in atherosclerosis. To determine the effect of this methodology on lesions, 16 male low density lipoprotein (LDL) receptor knockout (LDLr2/2) mice were reconstituted with bone marrow from syngeneic LDLr2/2 mice after 10 Gy g-irradiation and compared with 12 male LDLr2/2 littermates that di...

Evidenee that eonventional treatment (ehemotherapy and/or immunotherapy) produees a substantial number of eures in aeute myeloid leukaemia (AML) is laeking (PowIes et al. 1980a). Thomas et al. (1977) showed that there was a proportion of long-term survivors of a group of AML patients treated with high-dose eyc1ophosphamide, total body irradiation (TBI) and allogeneie bone marrow transplantation...

Isolated granulocytic sarcoma (GS) has rarely been reported in a patient who underwent allogeneic bone marrow transplantation (BMT) for chronic myelogenous leukemia (CML). We report here a patient who developed an isolated GS after achieving hematologic and cytogenetic remission by donor lymphocyte infusion for the relapse of CML following BMT. The size of GS was slightly decreased after local ...

Unlike allogeneic bone marrow transplantation (BMT), autologous BMT is not accompanied by immune-mediated graft-versus-leukemia (GVL) effects; hence, the relapse rate observed after autologous BMT in malignant hematologic disorders is higher than that observed after allogeneic BMT. Autologous BMT represents a much safer medical procedure available for many patients in need in situations where a...

To assess the clinical significance of minimal residual disease (MRD) detection by polymerase chain reaction (PCR) we analyzed samples from 26 patients with mantle cell lymphoma (MCL) who had undergone bone marrow transplantation (BMT) at the Dana-Farber Cancer Institute. The BCL-1/IgH translocation and clonally rearranged Ig heavy chain genes (IgH) provided molecular markers for detection and ...

Approximately 5% to 15% of patients undergoing bone marrow transplantation (BMT) develop fatal hepatic failure. Recently Frickhofen et al' have suggested that preexisting hepatitis C virus (HCV) infection may predispose to the development of liver failure after BMT whereas other investigators did not find such a correlation?' Because distinct HCV genotypes exist and have been shown to associate...

Autologous bone marrow transplantation (BMT) was utilized as therapy for 23 patients with acute lymphoblastic leukemia (All) in second or greater remission. Bone marrow was treated in vitro with a combination of monoclonal antibodies, consisting of BA-i . BA-2. BA-3, and baby rabbit complement (BRC’). All patients were prepared for transplantation with cyclosphosphamide and fractionated total b...

A retrospective analysis of the clinical features of 62 patients with various hematological or other diseases who received allogeneic stem cell transplantation (SCT) between April 1990 and July 2002 in the Department of Pediatrics, Kobe University Hospital was conducted to investigate prognostic factors of allo-SCT. Among 62 allo-SCT, 51 (82%) were bone marrow transplantation (BMT), 5 (8%) were...