S cientific research and the development of modern powerful techniques [1] are crucial for improving patient care in a society that is increasingly demanding the highest quality health services. Indeed, effective patient care requires the continuous improvement of knowledge on the pathophysiology of the diseases, diagnostic procedures and therapeutic tools available. To this end, development of...

The University of Hawai‘i (UH) at Manoa, John A. Burns School of Medicine received a research infrastructure award in November 2010 to advance clinical and translational research in health disparities reduction in Hawai‘i. Clinical and translational research refers to the translation of knowledge from the laboratory bench to the patient’s bedside and then to the larger community. The grant was ...

Dementia disorders are characterized by clinicopathological criteria. Molecular understandings of these disorders, based on immunohistochemical studies, biochemical investigations, genetic approaches, and animal models, have resulted in advances in diagnosis. Likewise, translational research has allowed us to apply our increasing basic scientific knowledge of neurodegeneration to the rational d...

Translational research (TR) involves both the development of novel diagnostics and novel therapeutics. These two major developmental areas are often associated with each other and these associations often bring new paradigms in the management of cancer patients. For example, the development of trastuzumab-based treatments has been conducted in harmony with the development of new methodologies t...

The advent of induced pluripotent stem cells (iPSCs) has revolutionized the concept of cellular reprogramming and potentially will solve the immunological compatibility issues that have so far hindered the application of human pluripotent stem cells in regenerative medicine. Recent findings showed that pluripotency is defined by a state of balanced lineage potency, which can be artificially ins...

Cholesterol plays a strategic role in liposome composition, however the quantity used to achieve an appropriate formulation has not been yet clarified. Therefore, by screening arrange of lipids and cholesterol ratio, the main aim of this study is to investigate the most suitable amount of cholesterol in lipids in order to prepare stable and controlled drug release vehicles. For the preparation ...

Spurred in part by the sequencing of the human genome, there has been increasing emphasis on the importance of translational research to convert biomedical discoveries in cancer into useful clinical applications. Heightened interest in translational research is reflected more generally in the growing prominence of evidence-based medicine and the perspective of population health. Factors contrib...