Translational medicine is a domain turning results of basic life science research into new tools and methods in a clinical environment, for example, as new diagnostics or therapies. Nowadays, the process of translation is supported by large amounts of heterogeneous data ranging from medical data to a whole range of -omics data. It is not only a great opportunity but also a great challenge, as t...

The Golden Helix Institute of Biomedical Research is an international nonprofit scientific organization with interdisciplinary research and educational activities in the field of genome medicine in Europe, Asia and Latin America. These activities are supervised by an international scientific advisory council, consisting of world leaders in the field of genomics and translational medicine. Resea...

William T.G. Morton, on October 16, 1846, demonstrated the use of ether anesthesia at the Massachusetts General Hospital. He opened a gateway to the translational medicine in modern anesthesiology and perioperative medicine. However, it took over 100 years before this compound was utilized for anesthetic purposes and eventually, the role of ether in modern medicine was replaced with safer drugs...

The challenge is to analyze these BIG DATA to answer clinical and biological questions by using appropriate statistical methods. With data on the machinery of a cell to the clinical status of individuals in any circumstances including in clinical trials, new tools are needed to translate information obtained from complex systems into knowledge. This has led to the field of « systems biology » a...

The European Academies Science Advisory Council has published a series of reports on infectious disease policy issues, analyzing priorities for building the science base as part of public health strategy. Among current challenges facing the European Union are the needs to tackle antibiotic resistance, promote vaccine innovation, prepare for the emergence of novel zoonoses, and integrate researc...

The Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC) represents a new model of cardiovascular research, in which emphasis is placed on close collaboration between basic and clinical researchers, both nationally and internationally, and on creating a network of relations with clinical institutions that will enable acquired knowledge to be efficiently transformed into real he...

Optoelectronic motion capture systems have been widely used to investigate temporal gait parameters in humans and animals in order to understand function and behavioural attributes of different pathologies, e.g. Parkinson's disease (PD). The aim of the present paper was to investigate the practicality of utilising this system to investigate the effects of a unilateral 6-hydroxydopamine (6-OHDA)...

It was seventeen years ago that a set of ideas that had been evolving over the previous three decades became embodied in a unifying term: evidence-based medicine. It is impossible to think of medicine today without reference to evidence-based medicine: as of April 2007, there were 25,000 entries in MEDLINE, 1.24 million Google-identified hits on the Internet, and over 300 books on the topic in ...

BACKGROUND As part of the American College of Surgeons verification to be a Level 1 trauma center, centers are required to have the capacity to identify trauma patients with risky alcohol use and provide an intervention. Despite supporting scientific evidence and national policy statements encouraging alcohol Screening, Brief Intervention and Referral to Treatment (SBIRT), barriers still exist,...

PURPOSE OF REVIEW The field of cystic fibrosis (CF) is changing dramatically as the scientific knowledge accumulated since the cloning of the cystic fibrosis transmembrane conductance regulator (CFTR) gene is being translated into effective therapies to correct the basic defect and provide better disease models and in-depth understanding of the basic mechanisms of disease. RECENT FINDINGS Thi...