The Polycomb Repressive Complex 2 (PRC2) mediates epigenetic gene silencing by trimethylating histone H3 lysine 27 (H3K27me3) and is known to aberrantly silence tumor suppressor genes in cancer. EZH2, the catalytic subunit of PRC2, enhances tumorigenesis and is commonly overexpressed in several types of cancer. Our microRNA profiling of bladder transitional cell carcinoma (TCC) patient samples ...

OBJECTIVE To determine the histological grading and muscle invasion in Transitional Cell Carcinomas of the Urinary Bladder; and to evaluate whether any correlation exists between tumour grade and muscle invasion. METHOD A Retrospective study of all consecutive cases of Transitional Cell Carcinomas of the Urinary Bladder diagnosed at Aga Khan University Hospital between 1st Jan 1997 and 31st D...

Brain metastasis from non muscle invasive transitional cell carcinoma of the urinary bladder occurs very rarely. Herein, a patient who underwent transurethral resection of bladder tumor and received intravesical bacillus CalmetteGuérin for pT1, G3 bladder carcinoma accompanied by carcinoma in situ, and who subsequently developed solitary cerebellar metastasis following 18 months cystoscopic fol...

PURPOSE Evaluation of Maspin marker in TCC of urine bladder, its grade, and stage, and also to compare Maspin expression in normal transitional cell epithelium and TCC in patients admitted to Modarres Hospital from 2009 to 2012. MATERIALS & METHODS Paraffin blocks of bladder tissue, from total number of 76 patients with TCC, and normal epithelium were included. Slides were prepared, and stain...

Histologic variants of prostatic carcinoma are readily recognized. In this report, we describe a rare variant, adenoid cystic carcinoma, in a 75-year-old man previously diagnosed to have transitional cell carcinoma of the urinary bladder. The diagnosis of adenoid cystic carcinoma was made by the characteristic microscopic features of the tumor morphologically and immunohistochemically. Two mont...

A panel of markers, selected for the suspected bladder cancer relevance of their corresponding genes, were explored for their expression and subcellular location in urinary bladder tissue. The expression in normal urothelium, in non-metastasised transitional cell carcinomas (TCC), and in primary metastasised TCC with corresponding metastases was mapped. Potential associations between the protei...

Prostate stem cell antigen (PSCA), a homologue of the Ly-6/Thy-1 family of cell surface antigens, is expressed by a majority of human prostate cancers and is a promising target for prostate cancer immunotherapy. In addition to its expression in normal and malignant prostate, we recently reported that PSCA is expressed at low levels in the transitional epithelium of normal bladder. In the presen...

BACKGROUND Early signs of canine transitional cell carcinoma (TCC) are frequently assumed to be caused by other lower urinary tract diseases (LUTD) such as urinary tract infections, resulting in late diagnosis of TCC which could be fatal. The development of a non-invasive clinical test for TCC could dramatically reduce mortality. To determine whether microRNAs (miRNAs) can be used as non-invasi...

sitional cell carcinoma, or TCC) of the urinary bladder is the 4th most common cancer among men and the 11th most common cancer among women in the United States, according to the American Cancer Society.1 An estimated 68,810 new cases of TCC of the bladder are expected to occur in 2008, resulting in 14,100 deaths.1 Outcomes are determined by several factors, including the stage and grade of the...

OBJECTIVE To describe for the first time the survival of bladder transitional cell carcinoma (TCC) in Indonesia, according to clinicopathological characteristics. MATERIALS AND METHODS Retrospective study of bladder TCC survival in a single institution, Cipto Mangunkusumo Hospital, Indonesia's national tertiary referral centre, between the years 1995 and 2005. The Kaplan-Meier method was used...