Haemochromatosis should currently refer to hereditary iron overload disorders presenting with a definite and common phenotype characterised by normal erythropoiesis, increased transferrin saturation and ferritin and primarily parenchymal iron deposition related to innate low (but normally regulated) production of the hepatic peptide hormone hepcidin. Since the discovery of the haemochromatosis ...

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OBJECTIVE This study is to investigate anemia management trends in patients on peritoneal dialysis in Huashan Hospital in the past 10 years. METHODS A total of 463 cases of patients receiving peritoneal dialysis from July 2004 to March 2014 were analyzed retrospectively. The patients enrolled in this study all were elder than 18 years old, those who had been followed up for at least 1 quarter...

OBJECTIVES Data have indicated low to non-existent increased mortality risk for individuals with prediabetes, but it is unclear if the risk is increased when the patient has elevated iron markers. Our purpose was to examine the mortality risk among adults with prediabetes in the context of coexisting elevated transferrin saturation (TS) or serum ferritin. SETTING Data collected by the third N...

BACKGROUND/AIMS Prohepcidin and the active form hepcidin-25 are two variants of the peptide hormone hepcidin for iron homoeostasis. Their regulatory role and usefulness as biomarkers of the iron status are uncertain. Our aim is to describe the intra-individual variance of serum and urinary hepcidin-25 and prohepcidin concentrations, the mutual associations of the 4 hepcidin formats, and their c...

BACKGROUND Haemochromatosis is associated with mutations in the HFE gene but the significance of these mutations in the general population is unknown. AIMS To determine the frequency of HFE gene mutations in the general population, their effect on serum iron indexes, and their role in screening for haemochromatosis. METHODS Deoxyribonucleic acid (DNA) from 1064 randomly selected subjects wa...

This report presents data obtained from a field study of the effects on the nutritional status of kindergarten children by providing either breakfast and lunch (BL Groups) or specific micronutrients in a fruitflavored drink (NC Groups) and two corresponding control groups. Some change in the nutritional status was observed in all four groups. In the BL Groups there was a change in the distribut...

Many health benefits are attributed to soy food intake, but data on mineral balance arelimited. Our main objective was to determine the effect of soy foods intake for 10-wk on ironor zinc status in women of childbearing age. We also tested the effect on bone and thyroid hormones. Women (18-28 y) non-smokers without chronic disease, anemia, pregnancy,and/or irregular menstrual cy...

Cardiosiderosis is a leading cause of mortality in transfusion-dependent thalassemias. Plasma non-transferrin-bound iron and its redox-active component, labile plasma iron, are key sources of iron loading in cardiosiderosis. Risk factors were identified in 73 patients with or without cardiosiderosis. Soluble transferrin receptor-1 levels were significantly lower in patients with cardiosiderosis...

10 500 blood donors from South Wales. This result differs from results in other studies in which an elevated transferrin saturation detected the predicted frequency of Cys282Tyr homozygotes in both a population of blood donors1 and in 65 000 individuals older than 20 years in a Norwegian county.2 The precise value of the transferrin saturation to be used as a “threshold” value in screening stud...