A new frontier in the administration of therapeutic drugs to veterinary species is transdermal drug delivery. The primary challenge in developing these systems is rooted in the wide differences in skin structure and function seen in species ranging from cats to cows. The efficacy of a transdermal system is primarily dependent upon the barrier properties of the targeted species skin, as well as ...

Transdermal drug delivery system has been accepted as potential noninvasive route of drug administration, with advantages of prolonged therapeutic effect, reduced side effects, improved bioavailability, better patient compliance and easy termination of drug therapy. Non-steroidal antiinflammatory drugs (NSAIDs) represents the most commonly used medications for the treatment of pain and inflamma...

OBJECTIVE To assess the risk of venous thrombosis in current users of non-oral hormonal contraception. DESIGN Historical national registry based cohort study. SETTING Four national registries in Denmark. PARTICIPANTS All Danish non-pregnant women aged 15-49 (n=1,626,158), free of previous thrombotic disease or cancer, were followed from 2001 to 2010. MAIN OUTCOME MEASURES Incidence rate...

Objective: The proposed work was aimed to formulation, characterization and optimization of transdermal patches nanoparticles eplerenone for efficient delivery the drug. Methods: Eplerenone were formulated by casting evaporation method. Transdermal made using combinations hydroxypropyl methylcellulose (HPMC), Eudragit RS 100. Physical evaluation (organoleptic properties, pH, weight uniformity, ...

Dissolving microneedles are a noninvasive transdermal drug delivery platform that offers painless needle-free patient treatment. Current strategies to control the kinetics of release from polymeric microneedle patches consist adjusting bulk polymer formulations and/or encapsulating cargo in controlled vehicles. Instead, this study, rates were altered by modifying surface properties using plasma...

Although the carcinogenic consequences of smoking are well known, further research is needed on the effects of smoking on musculoskeletal health and surgical outcomes. Orthopaedic perioperative complications of smoking include impaired healing, increased infection, delayed and/or impaired fracture union and arthrodesis, and inferior arthroplasty outcomes. The incorporation of smoking cessation ...

Cigarette smoking has been implicated in delayed fracture healing and fracture nonunion in human clinical studies as well as basic-science animal models. Nicotine has been frequently cited as the deleterious agent; however, in studies whose authors have examined the influence of nicotine on healing, negative results have appeared to be at least somewhat dose-dependent. The effects of nicotine o...

The objective of our present work was to prepare transdermal matrix patches containing the drug, diclofenac diethylamine with various polymeric combinations of polyvinylpyrrolidone and ethylcellulose and to study the mechanism of release of the drug from the patches and its skin permeation. Sorbitan monolaurate 20 (Span 20), a non-ionic surfactant was added to the concentrations (0.1% wt/vol), ...

AIM The feasibility of transdermal delivery of naloxone, an opioid antagonist, by anodal iontophoresis patches using Ag/AgCl electrodes was investigated. METHODS To examine the effect of current strength, species variation and drug concentration on skin permeability of naloxone, in vitro skin permeation studies were performed using rat dorsal skin and porcine ear skin as the membrane. To dete...

Smoking is a major risk factor for failure of coronary artery bypass grafts (CABG). Experiments were designed to determine effects of transdermal nicotine, independent of smoking, on structure and function of CABG. Saphenous veins were placed as CABG in untreated dogs (control) or in dogs treated with transdermal nicotine (one 11-mg or two 22-mg patches/day) for 5 wk. Serum nicotine and plasma ...