The objective of this study was to assess the transdermal delivery of drugs using iontophoresis with cation- and anion-exchange fibers as controlled drug delivery vehicles. Complexation of charged model drugs with the ion-exchange fibers was studied as a method to achieve controlled transdermal drug delivery. Drug release from the cation-exchange fiber into a physiological saline was dependent ...

MEMS (Micro Electro Mechanical System) design systems are used for the development of microneedles, which are used for drug delivery. The drug delivery through micronnedle is painless which is not in case of transdermal needles. In this paper the simulation and analysis of microneedle is presented. The typical structure of a microneedle is simulated for studies of the structural behavior of mic...

Transdermal route offers inherent advantages over other conventional routes for the delivery of drugs with systemic activity. Transdermal drug delivery provides a continuous mode of administration at rates approaching zero-order similar to that provided by an intravenous infusion.The greatest obstacle is the stratum corneum, the outermost layer of the skin, which is considered to form a primary...

One of the most promising frontiers of bioengineering is the controlled release of a therapeutic drug from a vehicle across the skin (transdermal drug delivery). In order to study the complete process, a multiphase mathematical model describing the dynamics of a substance between two porous coupled media of different properties and extents is presented. A system of partial differential equation...

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Transdermal drug delivery generated major interest among large pharmaceutical companies in the 1980s and 1990s due to potential advantages of avoidance of first-pass metabolism, avoidance of exposure to the chemical and biological conditions of the gastrointestinal tract, reduction or avoidance of adverse events, improved patient compliance. Ethosome delivery system was established to develop a...

The skin offers an accessible and convenient site for the administration of medications. To this end, the field of transdermal drug delivery, aimed at developing safe and efficacious means of delivering medications across the skin, has in the past and continues to garner much time and investment with the continuous advancement of new and innovative approaches. This review details the progress a...

Chest wall tuberculosis (TB) is an endemic disease with a large number of variants. The condition affects numerous parts of the body and can penetrate the skin to form chronic open ulcers. Current treatment methods include oral anti-TB drugs and surgery. However, conventional drug treatments are not effective due to the difficulty in achieving an effective local concentration, and certain patie...

Transdermal drug delivery offers several advantages, including avoidance of erratic absorption, absence of gastric irritation, painlessness, noninvasiveness, as well as improvement in patient compliance. With this mode of drug administration, there is no pre-systemic metabolism and it is possible to increase drug bioavailability and half-life. However, only a few molecules can be delivered acro...