Infertility as a vital process in human reproduction involves many couples worldwide. Although many genetic causes of infertility are known, the genetic basis of infertility in men is largely unknown. Therefore, the identification of genetic biomarkers in this field is important and genetic polymorphisms in key genes of the spermatogenesis pathway can be valuable biomarkers in this field. Gene'...

The Salvador-Warts-Hippo (Hippo) pathway is an evolutionarily conserved regulator of organ growth and cell fate. It performs these functions in epithelial and neural tissues of both insects and mammals, as well as in mammalian organs such as the liver and heart. Despite rapid advances in Hippo pathway research, a definitive role for this pathway in hematopoiesis has remained enigmatic. The hema...

In vivo and in vitro motoneuron survival depends on the support of neurotrophic factors. These factors activate signaling pathways related to cell survival or inactivate proteins involved in neuronal death. In the present work, we analyzed the involvement of the nuclear factor-κB (NF-κB) pathway in mediating mouse spinal cord motoneuron survival promoted by neurotrophic factors. This pathway co...

The hypothalamic decapeptide gonadotropin-releasing hormone (GnRH), acting via its receptors (GnRHRs) expressed in pituitary gonadotrophs, represents a critical molecule in control of reproductive functions in all vertebrate species. GnRH-activated receptors regulate synthesis of gonadotropins in a frequency-dependent manner. The number of GnRHRs on the plasma membrane determines the responsive...

Cardiometabolic disorders are among the leading causes of mortality in human population. Dietary polyphenols exert beneficial effects on cardiometabolic health humans. Molecular mechanisms, however, not completely understood. Aiming to conduct in-depth integrative bioinformatic analyses elucidate molecular mechanisms underlying protective health, we first conducted a systematic literature searc...

Drug resistance is a crucial obstacle to achieve satisfactory chemotherapeutic effects. Numerous studies have shown that the PI3K/Akt signaling pathway plays significant role in various processes of cellular events and tumor progression, while few focused on drug endothelial cells. The present study aims explore relationship anticancer drugs human microvessel cells (HMEC-1). We established stab...

background: sustainable and commercial production of taxol as an anti cancer drug is a critical point to its clinical application. nowadays, hazel because of rapid growth and wide range distribution is considered as an alternative source of taxol. objective: to increase taxol production the cdna encoding 3-hydroxy-3-methylglutaryl-coa reductase (hmgr) from iranian hazel (genebank accession numb...

objective(s): the purpose of this study was to conduct a meta-analysis on human micrornas (mirnas) expression data of endometriosis tissue profiles versus those of normal controls and to identify novel putative diagnostic markers. materials andmethods: pubmed, embase, web of science, ovid medline were used to search for endometriosis mirna expression profiling studies of endometriosis. the mirn...

transcatheter ablation of atrioventricular accessory pathway is the therapy of choice in symptomatic patients. the ablation of posteroseptal accessory pathways thas some important points due to its anatomical location. catheter ablation of posteroseptal accessory pathways via left side approach is time consuming with low success rate and higher complications. we performed successful transcathet...

background: echinococcus multilocularis is a tiny tapeworm, responsible for 0.3~0.5 million alveolar echinococcosis in humans. methods: we searched relevant papers published between 1981 and 2013 based on the database sources such as pubmed and google scholar, and collected and integrated the data for analysis. results: the parasite is able to use host-originated molecules to modulate its devel...