Targeted disruption of either c-Src or TNFR-associated factor 6 (TRAF6) in mice causes osteoclast dysfunction and an osteopetrotic phenotype, suggesting that both molecules play important roles in osteoclastic bone resorption. We previously demonstrated that IL-1 induces actin ring formation and osteoclast activation. In this study, we examined the relationship between IL-1/TRAF6-dependent and ...

Huntington disease (HD) is a neurodegenerative disorder caused by an expansion of polyglutamines in the first exon of huntingtin (HTT), which confers aggregation-promoting properties to amino-terminal fragments of the protein (N-HTT). Mutant N-HTT aggregates are enriched for ubiquitin and contain ubiquitin E3 ligases, thus suggesting a role for ubiquitination in aggregate formation. Here, we re...

EBV-encoded latent membrane protein 1 (LMP1) is critical for EBV-driven B-cell transformation and most EBV-associated malignancies and is also implicated in exacerbation of autoimmunity. LMP1 functionally mimics the TNFR superfamily member CD40, but LMP1-induced signals and downstream B-cell functions are amplified and sustained compared with those mediated by CD40. CD40 and LMP1 both depend up...

Hanan Selman Hessan and Ahmed Mohammed Abbas 563 Abstract Immune status was examined after tonsillectomy operations in 30 children with recurrent acute tonsillitis, their ages ranged between 3-10 years, were clinically diagnosed by ENT surgeon at AlHilla General Teaching Hospital and 10 apparently healthy children were included as a control in the study which lasted from February to May 2011 .I...

Tumor necrosis factor (TNF) receptor (TNFR) associated factor 6 (TRAF6) is a unique member of the TRAF family of adaptor proteins that is involved in both the TNF receptor superfamily and the interleukin-1 receptor (IL-1R)/Toll-like receptor (TLR) superfamily signal transduction pathways. The ability to mediate signals from both families of receptors implicates TRAF6 as an important regulator o...

Tumor necrosis factor (TNF) receptor associated factor 6 (TRAF6) is a crucial signaling molecule regulating a diverse array of physiological processes, including adaptive immunity, innate immunity, bone metabolism and the development of several tissues including lymph nodes, mammary glands, skin and the central nervous system. It is a member of a group of six closely related TRAF proteins, whic...

هديکچ ت یحارط یارب ديدج شور کي هلاقم نيا رد تيوق ارا یطخ زاف اب هدرتسگ هدننک ئ يم ه دوش . شور نيا تيوقت و لاسروسنارت لاتيجيد رتليف یژولوپوت نيب تهابش یانبم رب يم هدرتسگ هدننک دشاب . نيا یانبم رب رواجم هقبط ود نيب ريخات رادقم و هدننک تيوقت زا هقبط ره نيگ یژولوپوت رتليف هيروف طسب زا هدافتسا اب Raise Cosine يم نييعت یروط یسناکرف هلصاف رد هک دوش 0-40 GHz تيوقت یطخ زاف هصخشم یاراد هدننک دشاب ه...

* لوئســ م هدنســ يون : ،نارــ هت ناــ بايخ ،رســ نارهت ناــ بايخ رسنارهت ميرك هاگنامرد ،رفولين راولب ،بيغتسد نفلت : 44506655 email: [email protected] فده و هنيمز : اب نمزم سامت تارثا لاّلح اه ناسنا تملاس رب يلآ ي هـتفرگ رارـق يسررب دروم فلتخم تاعلاطم رد اه اب سامت نيب هجوت لباق طابترا رگناشن هك لاّلح اه تيرفنولورمولگ و تسا هدوب اه . ركراـم يسررب هعلاطم نيا زا فده يويلك تيمس هب ساسح يرا...

Amyloid β (Aβ) aggregates are the primary component of senile plaques in Alzheimer disease (AD) patient's brain. Aβ is known to bind p75 neurotrophin receptor (p75(NTR)) and mediates Aβ-induced neuronal death. Recently, we showed that NGF leads to p75(NTR) polyubiquitination, which promotes neuronal cell survival. Here, we demonstrate that Aβ stimulation impaired the p75(NTR) polyubiquitination...

The Toll-interleukin-1 receptor domain-containing adapter Mal (MyD88 adapter-like protein) is involved in Toll-like receptor (TLR)-2 and TLR4 signal transduction. However, no studies have yet identified a function for Mal distinct from the related adapter MyD88. In this study, we have identified a putative TRAF6 interaction site in Mal but not in MyD88 and we demonstrate that Mal can be co-immu...