In translational readthrough (TR) the ribosome continues extending the nascent protein beyond the first in-frame termination codon. Due to the lack of dedicated analyses of eukaryotic TR cases, the associated functional-evolutionary advantages are still unclear. Here, based on a variety of computational methods, we describe the structural and functional properties of previously proposed D. mela...

The thyroid hormone receptor (TR) belongs to the steroid/nuclear receptor superfamily of ligand-inducible transcription factors. Numerous studies using transient transfection assays have demonstrated that in the absence of thyroid hormone (T3), unliganded TR acts as a constitutive repressor of transcription on genes bearing TR-response elements. We examined the molecular mechanism of TR repress...

The thyroid hormone receptor (TR) belongs to the steroid/nuclear receptor superfamily of ligand-inducible transcription factors. Numerous studies using transient transfection assays have demonstrated that in the absence of thyroid hormone (T3), unliganded TR acts as a constitutive repressor of transcription on genes bearing TR-response elements. We examined the molecular mechanism of TR repress...

The concept of immune regulation/suppression has been well-established and, besides thymus-derived CD4+CD25+ regulatory T (TR) cells, it became clear that a variety of additional peripherally induced TR cells play vital roles in protection from many harmful immune responses including intestinal inflammation. In the present study, we have analyzed in vivo-induced Ag-specific CD4+ TR cells with r...

Changes in solvent environment greatly affect macromolecular structure and stability. To investigate the role of excluded volume in solvation, scaled-particle theory is often used to calculate delta G(tr)(ev), the excluded-volume portion of the solute transfer free energy, delta G(tr). The inputs to SPT are the solvent radii and molarities. Real molecules are not spheres. Hence, molecular radii...

Throughout history, handwriting has been the primary means of recording information that is persevered across both time and space. With the coming of the electronic document era, we are challenged with making an enormous amount of handwritten documents available for electronic access. Though many handwritten documents contain only handwriting, now, more are mixed with printed text, noise, and b...

Steps taken to alleviate under-reporting of transfusion reactions at a public sector hospital in Pakistan TO THE EDITOR: A transfusion reaction (TR) is any untoward event that occurs during or after blood transfusion and is not related to the patient's underlying illness. It has been estimated that about 10% of all transfusions carry the risk of an adverse event [1]. Both, infectious and non-in...

Trademark retrieval (TR) has become an important yet challenging problem due to an ever increasing trend in trademark applications and infringement incidents. There have been many promising attempts for the TR problem, which, however, fell impracticable since they were evaluated with limited and mostly trivial datasets. In this paper, we provide a large-scale dataset with benchmark queries with...

OBJECTIVE To explore the influences of migration to a Western country on obesity and related risk factors by comparing measures of body composition and energy balance-related behaviours between Turkish adolescents in Turkey (TR-TR) and adolescents from Turkish immigrant ethnicity in the Netherlands (TR-NL). DESIGN Cross-sectional survey or baseline intervention data from six Dutch school-base...

Maintenance of proper moisture and regulation of infection are simultaneously required to promote healing of pressure ulcers. Continuous use of water-rich ointment may often lead to excess moisture and induce edematous granulation tissue. Use of water soluble ointment may excessively absorb exudates and induce dry granulation tissue. Selection of appropriate topical ointment is desired to avoid...