نتایج جستجو برای: tpa therapy

تعداد نتایج: 659243  

پایان نامه :وزارت علوم، تحقیقات و فناوری - دانشگاه پیام نور - دانشگاه پیام نور استان یزد - دانشکده علوم 1390

در این پایان‏نامه مشتقات تتراهیدروبنزو[b]پیران‏ در حضور کاتالیست‏های اسیدی جامد بر پایه tpa/al-mcm-41 از تراکم مالونونیتریل، آلدهید و دای‏مدون، همچنین مشتقات زانتن‏دای‏اون‏ از تراکم دای مدون و آلدهید به نسبت 2 به 1 از دو واکنش‏گر سنتز شده‏اند. کاتالیست‏های 12–تنگستو فسفریک اسید نشانده شده بر روی al-mcm-41 (tpa/al-mcm-41) با مقادیر مختلف بارگذاری tpa و نسبت‏های مولی مختلف si/al سنتز و مشخصات آن...

Journal: :The American journal of emergency medicine 2016
Mohsen Sharifi Jeremy Berger Paul Beeston Curt Bay Zoltan Vajo Seyed Javadpoor

OBJECTIVE Pulseless electrical activity (PEA) during cardiac arrest portends a poor prognosis. There is a paucity of data in the use of thrombolytic therapy in PEA and cardiopulmonary arrest due to confirmed pulmonary embolism (PE). We evaluated the outcome of low-dose systemic thrombolysis with tissue plasminogen activator (tPA) in patients presenting with PEA due to PE. METHODS During a 34-...

Journal: :Archives of surgery 2007
Kevin J Bruen James R Ballard Stephen E Morris Amalia Cochran Linda S Edelman Jeffrey R Saffle

HYPOTHESIS Thrombolytic therapy will decrease the incidence of amputation when administered within 24 hours of exposure. DESIGN Single institution retrospective review of clinical outcomes and resource use. SETTING Burn unit of a tertiary academic referral center. PATIENTS From 2001 to 2006, patients with severe frostbite admitted within 48 hours of injury underwent digital angiography an...

Journal: :International journal of technology assessment in health care 1994
D E Levy T G Brott E C Haley J R Marler G L Sheppard W Barsan J P Broderick

BACKGROUND AND PURPOSE Several studies are currently evaluating tissue-type plasminogen activator (TPA) as a potential therapy in acute ischemic stroke. The possibility of inducing intracranial hematomas, however, introduces an important concern into ultimate evaluation of risk and benefit. This retrospective analysis sought to identify factors associated with intracranial hematoma formation in...

Journal: :Stroke 2013
Alexander C Flint Bonnie S Faigeles Sean P Cullen Hooman Kamel Vivek A Rao Rishi Gupta Wade S Smith Philip M Bath Geoffrey A Donnan

BACKGROUND AND PURPOSE In previous studies, the Totaled Health Risks in Vascular Events (THRIVE) score has shown broad utility, allowing prediction of clinical outcome, death, and risk of hemorrhage after tissue-type plasminogen activator (tPA) treatment, irrespective of the type of acute stroke therapy applied to the patient. METHODS We used data from the Virtual International Stroke Trials ...

2016
Wen-Cao Liu Xin-Chun Jin

The presence of a salvageable penumbra, a region of ischemic brain tissue with sufficient energy for short-term survival, has been widely agreed as the premise for thrombolytic therapy with tissue plasminogen activator (tPA), which remains the only United States Food and Drug Administration (FDA) approved treatment for acute ischemia stroke. However, the use of tPA has been profoundly constrain...

Journal: :Caspian journal of neurological sciences 2021

Background: Thrombolytic therapy is the recommended treatment of acute ischemic stroke. It crucial to evaluate results with recombinant Tissue Plasminogen Activator (r-TPA) in patients Objectives: This study aimed outcomes r-TPA stroke a referral center Iran. Materials & Methods: In this retrospective study, 87 symptoms were examined. They referred Gilan Province, Iran, from June 2016 April...

Journal: :Academic emergency medicine : official journal of the Society for Academic Emergency Medicine 2004
Andrew W Asimos H James Norton Marlow F Price Wilkie M Cheek

OBJECTIVES To describe the experience of a community teaching hospital emergency department (ED) Code Stroke Protocol (CSP) for identifying acute ischemic stroke (AIS) patients and treating them with tissue plasminogen activator (tPA) and to compare outcome measures with those achieved in the National Institute of Neurological Disorders and Stroke (NINDS) trial. METHODS This study was a retro...

Journal: :Stroke 2015
Miklos G Marosfoi Netanel Korin Matthew J Gounis Oktay Uzun Srinivasan Vedantham Erin T Langan Anne-Laure Papa Olivia W Brooks Chris Johnson Ajit S Puri Deen Bhatta Mathumai Kanapathipillai Ben R Bronstein Ju-Yu Chueh Donald E Ingber Ajay K Wakhloo

BACKGROUND AND PURPOSE The goal of this study is to combine temporary endovascular bypass (TEB) with a novel shear-activated nanotherapeutic (SA-NT) that releases recombinant tissue-type plasminogen activator (r-tPA) when exposed to high levels of hemodynamic stress and to determine if this approach can be used to concentrate r-tPA at occlusion sites based on high shear stresses created by sten...

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