Allostery plays a key role in the regulation of the activity and function of many biomolecules. And although many ligands act through allostery, no systematic use is made of it in drug design strategies. Here we describe a procedure for identifying the regions of a protein that can be used to control its activity through allostery. This procedure is based on the construction of a plausible conf...

Previous studies have identified an N-terminal saliva-binding region (SBR) on Streptococcus mutans surface antigen I/II (AgI/II) and suggested its importance in the initial adherence of S. mutans to saliva-coated tooth surfaces and subsequent development of dental caries. In this study, we compared the SBR with a C-terminal structural region of AgI/II (AgII) in their abilities to induce protect...

The International Transporter Consortium (ITC) has recently described seven transporters of particular relevance to drug development. Based on the second ITC transporter workshop in 2012, we have identified additional transporters of emerging importance in pharmacokinetics, interference of drugs with transport of endogenous compounds, and drug-drug interactions (DDIs) in humans. The multidrug a...

Toxin-antitoxin systems (TAs) are ubiquitous among bacteria and play a crucial role in the dissemination and evolution of antibiotic resistance, such as maintaining multi-resistant plasmids and inducing persistence formation. Generally, activities of the toxins are neutralised by their conjugate antitoxins. In contrast, antitoxins are more liable to degrade under specific conditions such as str...

cholera outbreak is more common in developing countries. the causative agent of the disease is vibrio cholerae strains o1 and o139. traditional diagnostic testing for vibrio is not always reliable, because vibrio can enter a viable but non cultivable state. therefore, nucleic acid-based tests have emerged as a useful alternative to traditional enrichment testing.       in this investigation, a ...

introduction:poisoning is a common reasons for hospitalization in all over the world and exhausts a substantial share of health resources.khoramabad is a rather large city in iran but there has been no study about incidence of poisoned patients especially grave ones who are hospitalized in icus, thus we designed this study to epidemiologicall assess these patients in two major referral centers ...

Brown spot disease caused by Alternaria alternata (Fr.: Fr.) Keissl is a serious problem forproduction of tangerines and tangerine hybrids in Iran. The Tangerine pathotype causes brownspot disease on young leaves and immature fruits of limited varieties of mandarins and tangerines(Citrus. reticulata Blanco). Specificity in the interaction between tangerine and the pathogen isdetermined by a hos...

In this paper, we present a new approach for solving absolute value equation (AVE) whichuse Levenberg-Marquardt method with conjugate subgradient structure. In conjugate subgradientmethods the new direction obtain by combining steepest descent direction and the previous di-rection which may not lead to good numerical results. Therefore, we replace the steepest descentdir...

In this study it has been tried, to compare results and convergence rate of sensitivity analysis and conjugate gradient algorithms to reduce fuel consumption and increasing engine performance by optimizing the timing of opening and closing valves in XU7/L3 engine. In this study, considering the strength and accuracy of simulation GT-POWER software in researches on the internal combustion engine...