The immense chemical diversity of plant-derived secondary metabolites coupled with their vast array of biological functions has seen this group of compounds attract considerable research interest across a range of research disciplines. Medicinal and aromatic plants, in particular, have been exploited for this biogenic pool of phytochemicals for products such as pharmaceuticals, fragrances, dyes...

Recent advances in microelectronics and biosensors are enabling developments of innovative biochips for advanced healthcare by providing fully integrated platforms for continuous monitoring of a large set of human disease biomarkers. Continuous monitoring of several human metabolites can be addressed by using fully integrated and minimally invasive devices located in the sub-cutis, typically in...

Marine ecosystem, covering over 70% of the Earth's area, is the place for a wide variety of animal and plant species whose number greatly exceeds that of terrestrial ones. Amongst those biodiversity, microbial world represents a potential research object to be explored as the recent investigations on marine microbes have given the impact to the entire world as a source of bioactive metabolites ...

OBJECTIVE The objective of this paper was to review the effectiveness of interventions to reduce pesticide overexposure and poisonings in worker populations. METHODS We used the Cochrane Collaboration search strategy to search the following databases for articles that tested the effectiveness of interventions in reducing human pesticide exposure or poisonings: MEDLINE, EMBASE, and Occupationa...

*Institut National de la Recherche Scientifique-Institut Armand-Frappier (INRS-IAF), Pointe-Claire, QC H9R 1G6, Canada †Departement of Fisheries and Oceans, Institut Maurice-Lamontagne, Mont-Joli, QC G5H 3Z4, Canada ‡Western College of Veterinary Medicine, University of Saskatchewan, Saskatoon, SK S7N 5B4, Canada §Biomedical Sciences, Ontario Veterinary College Medicine, Guelph, ON N1G 2W1, Can...

Azinphosmethyl (APM) is one of the most common insecticides used in fruit farming. The object of this paper is to develop a quick and practical test for assessing the risk for humans coming into contact with APM. It has been shown that the principal component of occupational and/or accidental exposure is through the skin (C. A. Franklin et al., 1981, J. Toxicol. Environ. Health 7, 715-731), but...

During the synthesis of the bulk drug Raloxifene hydrochloride, eight impurities were observed, four of which were found to be new. All of the impurities were detected using the gradient high performance liquid chromatographic (HPLC) method, whose area percentages ranged from 0.05 to 0.1%. LCMS was performed to identify the mass number of these impurities, and a systematic study was carried out...

BACKGROUND Intercourse in mammals is often coordinated with ovulation, for example through fluctuations in libido or by the acceleration of ovulation with intercourse. Such coordination has not been established in humans. We explored this possibility by examining patterns of sexual intercourse in relation to ovulation. METHODS Sixty-eight sexually active North Carolina women with either an in...

The main limitation of haemodialysis techniques is the scarce removal of solute in the range of middle to high molecular weight that may cause a progressive accumulation of these molecules with complications in the long term [1]. Moreover haemodialysis requires large amount of dialysate fluid for the removal of uremic metabolites placing a considerable cost burden on the health care provider. T...

It has been hypothesized that women who metabolize their endogenous estrogens predominantly via 16(alpha)-hydroxylation rather than via 2-hydroxylation and, as a result, have a low ratio of 2-hydroxyestrone (2-OHE1):16(alpha)-hydroxyestrone (16(alpha)-OHE1) are at an increased risk of breast cancer. Epidemiological evidence in support of this hypothesis is scarce and mostly based on measurement...