tuberculosis is an infectious disease caused by mycobacterium tuberculosis and is the primary cause of mortality in the world. m. tuberculosis strains are important intracellular pathogens causing infection in oxygen-rich macrophages in the lungs. the emergence of aids, declined socioeconomic standards and a lessened emphasis on tb control programs have contributed to the disease resurgence. re...

background: herbal distillates had been used for many centuries as herbal medicine in traditional persian medicine. recently, some studies claimed the presence of methanol in different types of herbal distillates which can cause different complications or even death as methanol is highly toxic. the main purpose of this study was to determine methanol content in the commonly-used industrial herb...

mrs. heidari, 53 developed ventricular fibrillation and cardiopulmonary arrest after receiving 15 ml lidocaine 2% for local anesthesia at the dr. shariati hospital cathlab. there was no identified risk factor for her arrest preoperatively. she had a history of exertional chest pain for about 5 years and an electrocardiogram showed only inverted t-waves at the time of angiography. the case is re...

a carbamazepine intoxication with attempt is a relatively common clinical problem that presenting with coma, respiratory depression, arrhythmia, hemodynamic instability and even death. we report a case of severe carbamazepine poisoning that was successfully treated with one session charcoal hemoperfusion. on admission, the patient was comatose and required ventilator support. hemoperfusion with...

herbicide toxicities are considered as an important issue in public health programs of developing countries. this investigation aims at studying epidemiologic toxicities caused by paraquat herbicide and comparing factors influencing these patients’ causality in kermanshah imam khomeini hospital. in a descriptive-survey study, 9 patients poisoned by paraquat herbicide were considered statistical...

Irinotecan unexpectedly causes severe toxicity of leukopenia or diarrhea. Irinotecan is metabolized to form active SN-38, which is further conjugated and detoxified by UDP-glucuronosyltransferase (UGT) 1A1 enzyme. Genetic polymorphisms of the UGT1A1 would affect an interindividual variation of the toxicity by irinotecan via the alternation of bioavailability of SN-38. In this case-control study...