Three cases are described in which Stevens-Johnson syndrome progressed in the course of a few days to toxic epidermal necrolysis. Trimethoprim-sulfamethoxazole, allopurinol in combination with hydrochlorothiazide, phenytoin and possibly ampicillin were implicated in the causation of the disease.

A 26-year-old male was referred from elsewhere for the evaluation of oral ulcers, joint pains, renal failure and had already received 2 weeks of oral prednisone. His immunological evaluation showed positive anti nuclear and anti-double-stranded antibodies. Renal histology at our hospital was suggestive of diffuse proliferative lupus glomerulonephritis and the patient was put on oral prednisone ...

Drugs are an important cause of Stevens–Johnson syndrome(SJS) in about 95% of reports. 100 drugs have been reported as causes of SJS or toxic epidermal necrolysis (TEN). There are very few reports of SJS due to use of diclofenac. In this report we present a 65 year old lady who developed SJS after usage of diclofenac suppository.