The interplay between 'noise-deficient' QSAR and Partial Order Ranking, including analysis of average linear ranks, constitutes an effective tool in giving substances which have not been investigated experimentally an identity by comparison with experimentally well-characterized, structurally similar compounds. It is disclosed that experimentally well-characterized compounds may serve as substi...

The effect of dimethyl sulphoxide and other cryoprotective compounds on the sensitivity of cells to polypeptide toxins and to poliovirus was tested. In the presence of these compounds, which all affect membrane fluidity, the cells were protected against the toxic proteins and against poliovirus. The large protection obtained was not due to reduced binding and endocytosis of the toxins. Apparent...

The infrastructure of the pericardial cells of adult female Drosophila melanogaster is illustrated. The data presented suggest that the pericardial cell internalizes by pinocytosis complex and possibly toxic compounds present in suspension in the haemolymph. These compounds are broken down to soluble molecules within lysosome-like vacuoles. The pericardial cells thus behave like the reticulo-en...

The liver is the major organ for removal of intestinally derived bacteria and toxic compounds, such as endotoxin, oxidants, and pro-oxidants. To detoxify these hazardous compounds, the liver contains high levels of low molecular weight antioxidants and enzymes that degrade reactive oxygen species. Reduced glutathione (GSH), vitamin C, vitamin E, superoxide dismutase (SOD), glutathione peroxidas...

Hexavalent chromium (VI) compounds are widely used in industry, while trivalent chromium (III) is used as a nutritional supplement. CrVI is generally considered more toxic and carcinogenic than its trivalent form and the toxicity of this metal is associated with free radical processes generating reactive oxygen species (ROS). The detailed mechanism of ROS formation by chromium and its compounds...

Alkylating agents and compounds converted metabolically to alkylating agents form an important class of carcinogens and mutagens that includes a number of environmentally important /V-nitrosocompounds. A number of alkylating agents are also useful antitumor drugs. There are many factors determining the sensitivity to the toxic, mutagenic, and carcinogenic poten tial of these compounds (1-4).2 O...

Data from the Total Exposure Assessment Methodology studies, conducted from 1980 to 1987 in New Jersey (NJ ) and California (CA) , and the 1990 California Indoor Exposure study were analyzed using positive matrix factorization, a receptor -oriented source apportionment model. Personal exposure and outdoor concentrations of 14 and 17 toxic volatile organic compounds (VOCs) were studied from the ...