INTRODUCTION Studies have shown that oxidative stress, found in patients with type 2 diabetes, may be due to changes in the metabolism of minerals, such as magnesium and iron. Data related to compartmentalization of these minerals in diabetes are scarce and controversial. OBJECTIVE This study assessed the influence of magnesium on biochemical parameters of iron and oxidative stress in patient...

Biochemical and haematological profiles of workers exposed to vanadium were compared with those of non-exposed age matched subjects. A significantly positive and dose related correlation between serum vanadium and zinc protoporphyrin (ZPP) was observed. Normal lead concentrations excluded this heavy metal as a possible cause. Inhibition of the reduction of Fe to Fe++ by vanadium is discussed as...

PURPOSE Soluble transferrin receptor (sTfR) is a truncated extracellular form of the membrane transferrin receptor produced by proteolysis. Concentrations of serum sTfR are related to iron status and erythropoiesis in the body. We investigated whether serum sTfR levels can aid in diagnosis and treatment of iron deficiency anemia (IDA) in children. METHODS Ninety-eight patients with IDA were e...

    Background: Iron is one of the nutrients that has recently received considerable attention because of its dual role in the incidence of breast cancer. The present study aimed at comparing hematological parameters, iron levels, and oxidative stress in women with and without breast cancer.    Methods: The participants in this case-control study were 55 women, of whom...

INTRODUCTION Our objective was to determine the interrelationships of interleukin (IL)-6 receptor inhibition with haemoglobin, acute-phase reactants and iron metabolism markers (including hepcidin) in patients with rheumatoid arthritis (RA). METHODS Data of patients receiving tocilizumab or placebo in the MEASURE study were analysed. We investigated associations at baseline and during tociliz...

COMMENTARY Is increased tissue ferritin a risk factor for atherosclerosis and ischaemic heart disease? In 1981 Sullivan postulated a link between tissue iron stores and the risk of heart disease' because both the incidence of ischaemic heart disease (IHD) and the serum concentration of ferritin are much lower in pre-menopausal women than in men of the same age, whereas in men and women over 45 ...

Using highly sensitive 2-site immunoradiometric assays, we examined the relationship between iron absorption from closed intestinal loops and transferrin and ferritin concentrations in isolated duodenal mucosal cells. As in prior studies, mucosal ferritin correlates inversely with iron absorption and directly with body iron stores as measured by the concentration of nonheme iron in liver. Mucos...

background and aims: iron deficiency anemia (ida) and beta thalassemia minor (btm) are the most common hypochromic microcytic anemias, and it is regarded important to differentiate between them. several formulae can be taken into consideration based on red blood cell (rbc) parameters in order to distinguish between these two disorders. hence, the present study intended to evaluate the sensitivi...