Objective: to analyze intra-hospital results in patients undergoing elective off-pump total arterial revascularization and identify morbidity and mortality predictors using this surgical strategy. Methods: From May 1999 to February 2004, 203 myocardial revascularization procedures with total arterial revascularization without cardiopulmonary bypass (off-pump) were carried out in patients with m...

Cardiopulmonary bypass (CPB) may introduce microemboli into the patient's arterial circulation. These may arise from the CPB circuit. Most relevant studies have been performed in vitro; there are relatively few clinical studies. We used the Emboli Detection and Classification quantifier (EDAC) (Luna Innovations, Roanoke, VA) in a prospective clinical audit of emboli in a contemporary CPB circui...

OBJECTIVE Evaluate the ability of clonidine to reduce pulmonary arterial pressure in patients with pulmonary hypertension undergoing heart surgery, either by reducing the pressure values from the direct measurement of pulmonary arterial pressure or by reducing or eliminating the need for intraoperative dobutamine and nitroprusside. METHOD Randomized, double-blind, placebo-controlled, comparat...

BACKGROUND/AIMS Renal ischemia/reperfusion injury (IRI) is a very common clinical event and usually leads to ischemic acute renal failure (ARF). In the present study, we investigated the protective role of vitamin C in renal function and renal arterial relaxation following ischemic injury. METHODS IRI model in mice was used. Various biochemical parameters including nitric oxide (NO), reduced ...

Venous shunt in cardiopulmonary physiology means that a fraction of the total cardiac output from the right side of the heart does not take part in gas exchange in the lungs and so passes unchanged into the arterial circulation (Berggren, 1942; Riley and Cournand, 1951; and Mcllroy, 1965). Since the shunted blood is mixed venous blood, the terms venous admixture, right-to-left shunt, and venous...