Many bacterial plasmids replicate by an asymmetric rolling-circle mechanism that requires sequence-specific recognition for initiation, nicking of one of the template DNA strands and unwinding of the duplex prior to subsequent leading strand DNA synthesis. Nicking is performed by a replication-initiation protein (Rep) that directly binds to the plasmid double-stranded origin and remains covalen...

A conformationally pre-organized ligand platform allows for restricted swivelling motions of two aryleneethynylene-appended 2,2'-bipyridyl units that function as a tight bischelator as well as a ratiometric fluorescence sensor for selected metal ions.

 In this paper, we consider a flexible skew-generalized normal distribution. This distribution is denoted by $FSGN(/lambda _1, /lambda _2 /theta)$. It contains the normal, skew-normal (Azzalini, 1985), skew generalized normal (Arellano-Valle et al., 2004) and skew flexible-normal (Gomez et al., 2011) distributions as special cases. Some important properties of this distribution are establi...

This paper aims to assess the application of Support Vector Machine (SVM) regression in order to analysis flexible pavements. To this end, 10000 Four-layer flexible pavement sections consisted of asphalt concrete layer, granular base layer, granular subbase layer, and subgrade soil were analyzed under the effect of standard axle loading using multi-layered elastic theory and pavement critical r...

in this paper a novel direct adaptive fuzzy system is proposed to control flexible-joints robot including actuator dynamics. the design includes two interior loops: the inner loop controls the motor position using proposed approach while the outer loop controls the joint angle of the robot using a pid control law. one novelty of this paper is the use of a pso algorithm for optimizing the contro...

joint flexibility is a very important factor to consider in the controller design for robot manipulators if high performance is expected. most of the research works on control of flexible-joint robots in literature have ignored the actuator dynamics to avoid complexity in controller design. the problem of designing nonlinear controller for a class of single-link flexible-joint robot manipulator...

in this paper, finding dynamic load carrying capacity (dlcc) of flexible link manipulators in point to-point motion was formulated as an optimal control problem. the finite element method was employed for modelling and deriving the dynamic equations of the system. the study employed indirect solution of optimal control for system motion planning. due to offline nature of the method, many diffic...

this study investigates and compares the efficacy of differentiated instruction and traditional-based instruction on enhancing iranian students’ reading comprehension. eight elementary, intermediate, and advanced classrooms from 1 language institute were chosen, and based on their performance on the pretests were further divided into 4 control and 4 treatment groups. flexible grouping, tiered i...