A 2-year-old girl was referred to the Harapan Kita National Heart Center due return of spontaneous circulation after cardiac arrest, bradyarrhythmia and repeated seizures with loss consciousness. She had been treated an epilepsy drug for 1 year. Electrocardiography during one episode showed complete heart block junctional escape rhythm QT interval prolongation, which then progressed torsades de...

Long-QT syndrome (LQTS) is an inherited cardiac disease that is characterised by prolongation of the QT interval on the electrocardiogram and is associated with syncopal episodes, dangerous ventricular arrhythmias of the torsades de pointes type, and a high risk of sudden death on a substrate of a structurally normal heart. Today we know that LQTS is an inherited autosomal dominant arrhythmogen...

The QT interval represents ventricular depolarisation and repolarisation. Prolongation of this interval can lead to life-threatening complications. These can include arrhythmias such as Torsades de Pointes and Ventricular Fibrillation, which may ultimately lead to death. Many risk factors have been identified in prolonging the QT interval, one of which is medication commonly used in the treatme...

Prolongation of the QT interval on the surface 12-lead electrocardiogram is widely accepted as a biomarker for the potential of a drug to produce torsades de pointes and/or sudden death. Detection of drug-induced prolongation of the QT interval in animals and man is frequently confounded by extrinsic and intrinsic factors that limit the ability to detect a true drug effect. In particular drugs ...

Corresponding author: Yong Seon Choi, M.D., Department of Anesthesiology and Pain Medicine, Anesthesia and Pain Research Institute, Yonsei University College of Medicine, 50, Yonsei-ro, Seodaemun-gu, Seoul 120-752, Korea. Tel: 82-2-2227-4576, Fax: 82-2-364-2951, E-mail: [email protected] This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial L...

Takotsubo cardiomyopathy, also known as stress-induced cardiomyopathy, is a disease in which the patient exhibits transient, reversible left ventricular dysfunction that is triggered by physical or emotional stress. Prolongation of QT interval, a risk factor for arrhythmia and sudden death, has been reported to be prevalent among patients with Takotsubo cardiomyopathy and is also observed in th...

Many pharmaceutical agents interact with cardiac ion channels resulting in abnormal ventricular repolarization and prolongation of the QT interval. In rare circumstances, this has resulted in the development of the potentially life-threatening arrhythmia, torsades de pointes. It is recognized, however, that accurate measurement of the QT interval is challenging, and it is a poor predictor for t...