Both the ERCC1-XPF complex and the proteins involved in homoIogous recombination (HR) have critical roles in inter-strand cross-link (ICL) repair. Here, we report that mitomycin C-induced lesions inhibit replication fork elongation. Furthermore, mitomycin C-induced DNA double-strand breaks (DSBs) are the result of the collapse of ICL-stalled replication forks. These are not formed through repli...

To investigate the mechanism of cold adaptation of isocitrate lyase (ICL; EC 4.1.3.1) from the psychrophilic bacterium Colwellia maris, Gln207 and Gln217 of this enzyme were substituted by His and Lys, respectively, by site-directed mutagenesis. His184 and Lys194 of ICL from Escherichia coli, corresponding to the two Gln residues of C. maris ICL, are highly conserved in the ICLs of many organis...

The Fanconi Anemia (FA) signaling pathway is essential for the maintenance of genome integrity and cells to survive DNA interstrand crosslink (ICL) by coordinating DNA damage repair through translesion DNA synthesis (TLS), nucleotide excision repair (NER) and homologous recombination (HR). Besides ICL, the FA signaling pathway is activated by different kinds of genotoxins and plays an important...

2 Toric Varieties 7 2.1 Constructing an atlas for a toric variety from a fan . . . . . . . . . . . . . . . . . . . . 7 2.2 Cones correspond to torus orbits . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 8 2.3 Singularities . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 8 2.4 Maps of fans . . . . . . . . . . . . . . . . . . . . . . . . . . . . . ...

The Visian Implantable Collamer Lens ([ICL] STAAR Surgical, Monrovia, CA) is a ciliary sulcusplaced posterior chamber intraocular lens used in the management of high myopia in phakic patients.1 Because of the risk of cataract, ICL vaulting greater than 250 μm is recommend to reduce rubbing of the ICL on the crystalline lens. However, excessive vaulting greater than 750 μm increases the risk of ...

We characterize the orientability of an abstract real toric variety as well as the orientability of a toric subvariety of a sphere. We also determine the number of components of the smooth locus of a toric variety. These results are proven for an extension of the Davis-Januskiewicz notion of a small cover to singular spaces. We characterize the orientability of toric varieties associated to pos...

We define toric partial orders, corresponding to regions of graphic toric hyperplane arrangements, just as ordinary partial orders correspond to regions of graphic hyperplane arrangements. Combinatorially, toric posets correspond to finite posets under the equivalence relation generated by converting minimal elements into maximal elements, or sources into sinks. We derive toric analogues for se...

For a complete, smooth toric variety Y , we describe the graded vector space T 1 Y . Furthermore, we show that smooth toric surfaces are unobstructed and that a smooth toric surface is rigid if and only if it is Fano. For a given toric surface we then construct homogeneous deformations by means of Minkowski decompositions of polyhedral subdivisions, compute their images under the Kodaira-Spence...

We give equivalent and sufficient criteria for the automorphism group of a complete toric variety, respectively a Gorenstein toric Fano variety, to be reductive. In particular we show that the automorphism group of a Gorenstein toric Fano variety is reductive, if the barycenter of the associated reflexive polytope is zero. Furthermore a sharp bound on the dimension of the reductive automorphism...

We report the first case of secondary implantation of implantable collamer lens (ICL) for correction of anisometropic hyperopia in a 3-year-old pseudophakic child. The ICL implantation was considered in our patient due to parental noncompliance for contact lens and spectacles use for one year. In terms of efficacy, the preoperative refractive error of +7.00-1.75 diopter (D) reduced to +1.00-1.7...