Although the role of stiffness on proliferative response of cancer cells has been well studied, little is known about the effect of topographic cues in guiding cancer cell proliferation. Here, we examined the effect of topographic cues on cancer cell proliferation using micron scale topographic features and observed that anisotropic features like microgratings at specific dimension could reduce...

Contour line is the main linear feature on topographic maps. Extraction of contour lines is tedious and time-consuming process, and is still an interesting problem. A novel method for extraction of contour lines from paper-based topographic maps is presented in this paper. In our approach, we firstly segment color topographic maps for achieving the binary image of brown color contour lines. The...

This paper demonstrates how a new shape from shading scheme can be used to extract topographic information from 2D intensity imagery. The shape-from-shading scheme has two novel ingredients. Firstly, it uses a geometric update procedure which allows the image irradiance equation to be satisfied as a hard-constraint. This not only improves the data-closeness of the recovered needle-map, but also...

PURPOSE To evaluate programmed versus achieved laser-assisted in situ keratomileusis (LASIK) flap central thickness and investigate topographic flap thickness variability, as well as the effect of potential epithelial remodeling interference on flap thickness variability. PATIENTS AND METHODS Flap thickness was investigated in 110 eyes that had had bilateral myopic LASIK several years ago (av...

A kernel version of Generative Topographic Mapping, a model of the manifold learning family, is defined in this paper. Its ability to adequately model non-i.i.d. data is illustrated in a problem concerning the identification of protein subfamilies from protein sequences.

Object representation in the inferior temporal cortex (IT), an area of visual cortex critical for object recognition in the primate, exhibits two prominent properties: (1) objects are represented by the combined activity of columnar clusters of neurons, with each cluster representing component features or parts of objects, and (2) closely related features are continuously represented along the ...

The question of whether impact basins dating from the time of heavy bombardment of the inner solar system are preserved on the surface of Venus is of paramount importance for an understanding of the geological processes that have shaped that planet. Two types of features have been suggested as candidates for impact basins on Venus: (1) large, quasi-circular topographic depressions and (2) large...

Hepatocytes, the main epithelial cell type in the liver, perform most of the biochemical functions of the liver. Thus, maintenance of a primary hepatocyte phenotype is crucial for investigations of in vitro drug metabolism, toxicity, and development of bioartificial liver constructs. Here, we report the impact of topographic cues alone and in combination with soluble signals provided by encapsu...

BACKGROUND/AIMS While it is well established that acupuncture relieves somatic pain, its therapeutic effect on visceral pain such as irritable bowel syndrome (IBS) is unclear. We evaluated the effect of acupuncture in treating visceral hyperalgesia in an animal model. METHODS Sprague-Dawley rats (n = 8 per group) with prior neonatal maternal separation stress were randomly allocated to receiv...